Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission.
Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission.
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DOI：
10.1086/600103
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发表时间：
2009-08-01
期刊：
影响因子：
--
通讯作者：
Martin JN
中科院分区：
文献类型：
--
作者：
Butler LM;Dorsey G;Hladik W;Rosenthal PJ;Brander C;Neilands TB;Mbisa G;Whitby D;Kiepiela P;Mosam A;Mzolo S;Dollard SC;Martin JN
卡波西肉瘤相关疱疹病毒（KSHV）感染是非洲成年人群中的地方性疾病。一种普遍的观点是，儿童传播是整个非洲大陆观察到的成人KSHV高血清阳性率的主要原因。然而，很少有研究直接检查儿童，特别是在KS不普遍流行的地区。参与者为年龄在1.5 - 8.9岁之间的儿童，包括427名来自南非以人群为基础的儿童，422名来自乌干达以人群为基础的样本，567名来自乌干达以诊所为基础的样本。所有血清标本均在同一实验室进行KSHV抗体检测，使用2种酶免疫测定法（针对K8.1和ORF65）和1种免疫荧光测定法。南非儿童KSHV血清患病率为7.5% ~ 9.0%，与年龄无关。相比之下，在乌干达以人群为基础的样本中，KSHV血清患病率从2岁儿童的10%上升到8岁儿童的30.6% （p趋势< 0.001）。在乌干达的临床样本中，血清患病率从2岁儿童的9.3%上升到8岁儿童的36.4% （p趋势< 0.001）。儿童中年龄与KSHV感染之间的两种截然不同的关系意味着，在整个非洲，KSHV在儿童中的传播并不均匀，因此并不总是导致成人中观察到的高血清阳性率。在非洲至少有两种KSHV传播模式。
Kaposi sarcoma–associated herpesvirus (KSHV) infection is endemic among adult populations in Africa. A prevailing view is that childhood transmission is primarily responsible for the high seroprevalence of KSHV among adults that is observed throughout the continent. However, few studies have directly examined children, particularly in locations where KS is not commonly endemic. Participants were children aged 1.5−8.9 years, including 427 children from a population-based sample in South Africa, 422 from a population-based sample in Uganda, and 567 from a clinic-based sample in Uganda. All serum specimens were tested by the same laboratory for KSHV antibodies with use of 2 enzyme immunoassays (against K8.1 and ORF65) and 1 immunofluorescence assay. KSHV seroprevalence was 7.5%−9.0% among South African children and was not associated with age. In contrast, in the Ugandan population-based sample, KSHV seroprevalence increased from 10% among 2-year-old children to 30.6% among 8-year-old children (Ptrend < .001). In the Ugandan clinic-based sample, seroprevalence increased from 9.3% among 2-year-old children to 36.4% among 8-year-old children (Ptrend < .001). Two distinct relationships between age and KSHV infection among children imply that KSHV transmission among children is not uniform throughout Africa and is therefore not always responsible for the high seroprevalence observed in adults. There are at least 2 patterns of KSHV transmission in Africa.
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