Healthy Sleep Patterns and Risk of Incident Arrhythmias.
Healthy Sleep Patterns and Risk of Incident Arrhythmias.
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DOI：
10.1016/j.jacc.2021.07.023
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发表时间：
2021-09-21
影响因子：
24
通讯作者：
Qi L
中科院分区：
文献类型：
--
作者：
Li X;Zhou T;Ma H;Huang T;Gao X;Manson JE;Qi L
Emerging evidence has linked sleep behaviors with the risk of cardiac arrhythmias. The various sleep behaviors are typically correlated; however, most of the previous studies only focused on the individual sleep behavior, without considering the overall sleep patterns. To prospectively investigate the associations between a healthy sleep pattern with the risks of cardiac arrhythmias. A total of 403,187 participants from UK Biobank were included. A healthy sleep pattern was defined by chronotype, sleep duration, insomnia, snoring, and daytime sleepiness. Weighted genetic risk score (GRS) for atrial fibrillation was calculated. The healthy sleep pattern was significantly associated with lower risks of AF [hazard ratio (HR) comparing extreme categories: 0.71, 95% confidence interval (CI): 0.64–0.80] and bradyarrhythmia (HR: 0.65, 95% CI: 0.54–0.77), but not ventricular arrhythmias, after adjustment for demographic, lifestyle, and genetic risk factors. Compared with individuals with a healthy sleep score of 0–1 (poor sleep group), those with a healthy sleep score of 5 had a 29% and 35% lower risk of developing AF and bradyarrhythmia, respectively. Additionally, the genetic predisposition to AF significantly modified the association of the healthy sleep pattern with the risk of AF (p-interaction=0.017). The inverse association of the healthy sleep pattern with the risk of AF was stronger among those with a lower genetic risk of AF. Our results indicate that a healthy sleep pattern is associated with lower risks of AF and bradyarrhythmia, independent of the traditional risk factors; and the association with AF is modified by genetic susceptibility. We found that the newly developed healthy sleep pattern was associated with lower risks of AF and bradyarrhythmia, independent of the traditional risk factors. In addition, the inverse association of the healthy sleep pattern with the risk of atrial fibrillation/atrial flutter (AF) was stronger among those with a lower genetic risk of AF. Our findings suggest that the newly generated healthy sleep pattern may be a potentially important clinical tool to recommend for the prevention of cardiac arrhythmias.
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DOI：
10.1007/s11325-020-02046-9
发表时间：
2020-09
期刊：
Sleep & breathing = Schlaf & Atmung
影响因子：
--
作者：
Full KM;Lutsey PL;Norby FL;Alonso A;Soliman EZ;Rooney MR;Chen LY
通讯作者：
Chen LY
影响因子：
2
作者：
DURRLEMAN, S;SIMON, R
通讯作者：
SIMON, R
影响因子：
2.8
作者：
Khawaja, Owais;Sarwar, Akmal;Albert, Christine M.;Gaziano, John Michael;Djousse, Luc
通讯作者：
Djousse, Luc
影响因子：
2.1
作者：
Chokesuwattanaskul, Ronpichai;Thongprayoon, Charat;Cheungpasitporn, Wisit
通讯作者：
Cheungpasitporn, Wisit
DOI：
10.1161/circoutcomes.110.958165
发表时间：
2011-05-01
影响因子：
6.9
作者：
Kim, Michael H.;Johnston, Stephen S.;Schulman, Kathy L.
通讯作者：
Schulman, Kathy L.