Self-Organized Attractor Dynamics in the Developing Head Direction Circuit.
Self-Organized Attractor Dynamics in the Developing Head Direction Circuit.
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DOI：
10.1016/j.cub.2018.01.010
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发表时间：
2018-02-19
期刊：
影响因子：
--
通讯作者：
Cacucci F
中科院分区：
文献类型：
--
作者：
Bassett JP;Wills TJ;Cacucci F
头部方向（HD）细胞是在扩展的皮质和皮质下网络中发现的神经元，其发出动物头部相对于其环境的方向的信号。它们是构成空间神经认知图的更广泛的空间响应海马结构神经元回路的基本组成部分。在出生后的发育过程中，HD细胞是海马回路中空间调制神经元中第一个表现出成熟放电特性的细胞，但在睁眼之前，大鼠幼崽中的HD细胞反应具有低方向信息并且方向不稳定。使用贝叶斯解码的HD细胞系综活动记录在丘脑前背核（ADN），我们描述了这种不稳定性，并确定其来源：下信号的头部角速度，不完全转移的方向信号成比例的头部转动。我们发现的证据表明，几何线索（一个正方形环境的角落）可以用来减轻这种信号不足，从而稳定的方向信号，甚至在睁眼之前。至关重要的是，即使定向放电不能稳定，不稳定HD细胞的集合也显示出与成人样HD网络一致的短时间尺度（1-10秒）时间和空间耦合。HD网络被广泛地建模为连续吸引子，其输出是一个相干活动峰值，在运动期间通过头部角速度信号更新并通过地标线索锚定。我们的研究结果为这个模型提供了强有力的证据，他们表明，所需的网络电路在开发过程中的早期就已经到位并发挥作用，独立于地标信息的参考。非视觉线索可以锚头方向（HD）细胞在眼睛睁开前的大鼠幼崽内部网络动态被保存，即使当HD表示是不稳定的角速度下的信号驱动不稳定，这是缓解的角落电路架构发展，甚至在任何地标可以稳定HD响应Bassett et al。显示吸引子架构的头部方向（HD）电路的发展没有参考地标。非视觉线索可以稳定13天或更大的幼鼠的HD反应。视觉前HD细胞中的不稳定性是由信号传导下的角速度引起的，通过接近方形外壳中的角落来减轻。
Head direction (HD) cells are neurons found in an extended cortical and subcortical network that signal the orientation of an animal’s head relative to its environment. They are a fundamental component of the wider circuit of spatially responsive hippocampal formation neurons that make up the neural cognitive map of space. During post-natal development, HD cells are the first among spatially modulated neurons in the hippocampal circuit to exhibit mature firing properties, but before eye opening, HD cell responses in rat pups have low directional information and are directionally unstable. Using Bayesian decoding of HD cell ensemble activity recorded in the anterodorsal thalamic nucleus (ADN), we characterize this instability and identify its source: under-signaling of angular head velocity, which incompletely shifts the directional signal in proportion to head turns. We find evidence that geometric cues (the corners of a square environment) can be used to mitigate this under-signaling and, thereby, stabilize the directional signal even before eye opening. Crucially, even when directional firing cannot be stabilized, ensembles of unstable HD cells show short-timescale (1–10 s) temporal and spatial couplings consistent with an adult-like HD network. The HD network is widely modeled as a continuous attractor whose output is one coherent activity peak, updated during movement by angular head velocity signals and anchored by landmark cues. Our findings present strong evidence for this model, and they demonstrate that the required network circuitry is in place and functional early during development, independent of reference to landmark information. Non-visual cues can anchor head direction (HD) cells in pre-eye-opening rat pups Internal network dynamics are preserved even when the HD representation is unstable Angular velocity under-signaling drives instability, which is mitigated by corners Circuit architecture develops even before any landmarks can stabilize HD responses Bassett et al. show that the attractor architecture of the head direction (HD) circuit develops without reference to landmarks. Non-visual cues can stabilize HD responses in rat pups aged 13 days or older. Instability in pre-visual HD cells is caused by angular velocity under-signaling, mitigated by proximity to corners in square enclosures.
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