Intermittent Light Exposures in Humans: A Case for Dual Entrainment in the Treatment of Alzheimer's Disease.
Intermittent Light Exposures in Humans: A Case for Dual Entrainment in the Treatment of Alzheimer's Disease.
复制标题
DOI：
10.3389/fneur.2021.625698
复制
发表时间：
2021
影响因子：
3.4
通讯作者：
Leggett S
中科院分区：
文献类型：
--
作者：
Figueiro MG;Leggett S
昼夜节律睡眠障碍在美国成年人中很常见，在老年人中尤其严重，特别是那些患有阿尔茨海默病(AD)和轻度认知障碍(MCI)的人，导致症状恶化，并有助于疾病的发展和进展。这篇综述探讨了昼夜睡眠障碍、认知和神经退行性疾病之间的联系，为快速开发利用间歇性光刺激改善AD和MCI患者的睡眠和认知的治疗干预提供了见解。光疗可能通过至少两条途径影响睡眠和认知：(1)规则而强大的明暗模式到达视网膜，促进昼夜相移，从而促进携带；(2)40赫兹闪烁的光，促进伽马波携带。虽然这是一个新的研究领域，但初步证据表明，双重昼夜节律和伽马波夹带不仅对阿尔茨海默病患者，而且对其他认知障碍患者，都有潜力成为一种重要的治疗方法。
Circadian sleep disorders are common among American adults and can become especially acute among older adults, especially those living with Alzheimer's disease (AD) and mild cognitive impairment (MCI), leading to the exacerbation of symptoms and contributing to the development and advancement of the diseases. This review explores the connections between circadian sleep disorders, cognition, and neurodegenerative disease, offering insights on rapidly developing therapeutic interventions employing intermittent light stimuli for improving sleep and cognition in persons with AD and MCI. Light therapy has the potential to affect sleep and cognition via at least two pathways: (1) a regular and robust light-dark pattern reaching the retina that promotes circadian phase shifting, which can promote entrainment and (2) 40 Hz flickering light that promotes gamma-wave entrainment. While this is a new area of research, preliminary evidence shows the potential of dual circadian and gamma-wave entrainment as an important therapy not only for those with AD, but for others with cognitive impairment.
登录
查看更多内容
影响因子：
16.2
作者：
Bosman CA;Schoffelen JM;Brunet N;Oostenveld R;Bastos AM;Womelsdorf T;Rubehn B;Stieglitz T;De Weerd P;Fries P
通讯作者：
Fries P
影响因子：
13.9
作者：
Buzsáki G;Wang XJ
通讯作者：
Wang XJ
影响因子：
2.5
作者：
Arvanitogiannis, A;Amir, S
通讯作者：
Amir, S
影响因子：
13.6
作者：
Damisah, Eyiyemisi C.;Hill, Robert A.;Grutzendler, Jaime
通讯作者：
Grutzendler, Jaime
影响因子：
2
作者：
Backhaus, Jutta;Born, Jan;Junghanns, Klaus
通讯作者：
Junghanns, Klaus