Pharmacological enhancement of drug cue extinction learning: translational challenges.
Pharmacological enhancement of drug cue extinction learning: translational challenges.
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DOI：
10.1111/j.1749-6632.2010.05899.x
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发表时间：
2011-01
影响因子：
5.2
通讯作者：
Nic Dhonnchadha BÁ
中科院分区：
文献类型：
--
作者：
Kantak KM;Nic Dhonnchadha BÁ
Augmentation of cue exposure (extinction) therapy with cognitive-enhancing pharmacotherapy may constitute a rational strategy for the clinical management of drug relapse. While certain success has been reported for this form of therapy in anxiety disorders, in this article we highlight several obstacles that may undermine the efficacy of exposure therapy for substance use disorders. We also review translational studies that have evaluated the facilitative effects of the cognitive enhancer D-cycloserine on extinction targeting drug-related cues. Finally, important considerations for the design and implementation of future studies evaluating exposure therapy combined with pharmacotherapy for substance use disorders are discussed.
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