A study of the reproducibility and etiology of diffusion anisotropy differences in developmental stuttering: a potential role for impaired myelination.
A study of the reproducibility and etiology of diffusion anisotropy differences in developmental stuttering: a potential role for impaired myelination.
复制标题
DOI：
10.1016/j.neuroimage.2010.05.011
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发表时间：
2010-10-01
期刊：
影响因子：
5.7
通讯作者：
Robin, D. A.
中科院分区：
文献类型：
--
作者：
Cykowski, M. D.;Fox, P. T.;Ingham, R. J.;Ingham, J. C.;Robin, D. A.
关键词：
几项扩散张量成像（DTI）研究报告了持续性发育性口吃（PS）患者左侧外侧裂周白色物质（WM）的各向异性分数（FA）降低。然而，这些研究在左外侧裂周区域外FA差异的存在、空间分布（局灶性/弥漫性）和方向性（升高/降低）方面没有得出相同的结论。此外，补充DTI测量（轴向和径向扩散率，扩散迹线）尚未用于检查这些FA减少的潜在病因。因此，本研究试图通过性别和年龄控制的复制分析，重新审视早期的研究结果，然后扩展这些研究结果与上述非FA措施。复制分析表明，强大的FA减少PS主要是局灶性的，左半球，并在晚髓鞘的联合和连合纤维（第三节的左侧上级纵束，胼胝体，钳小胼胝体）。额外的DTI测量结果显示，这些FA减少归因于垂直于受影响纤维束的扩散增加（径向扩散率升高）。这些发现表明一个假设，将在未来的研究中进行检验：即骨髓生成可能是异常的PS内左半球的纤维束，开始一个长期的髓鞘形成过程中的第一个出生后的一年。
Several diffusion tensor imaging (DTI) studies have reported fractional anisotropy (FA) reductions within the left perisylvian white matter (WM) of persistent developmental stutterers (PSs). However, these studies have not reached the same conclusions in regard to the presence, spatial distribution (focal/ diffuse), and directionality (elevated/reduced) of FA differences outside of the left perisylvian region. In addition, supplemental DTI measures (axial and radial diffusivities, diffusion trace) have yet to be utilized to examine the potential etiology of these FA reductions. Therefore, the present study sought to reexamine earlier findings through a sex- and age-controlled replication analysis and then to extend these findings with the aforementioned non-FA measures. The replication analysis showed that robust FA reductions in PSs were largely focal, left hemispheric, and within late-myelinating associative and commissural fibers (division III of the left superior longitudinal fasciculus, callosal body, forceps minor of the corpus callosum). Additional DTI measures revealed that these FA reductions were attributable to an increase in diffusion perpendicular to the affected fiber tracts (elevated radial diffusivity). These findings suggest a hypothesis that will be testable in future studies: that myelogenesis may be abnormal in PSs within left-hemispheric fiber tracts that begin a prolonged course of myelination in the first postnatal year.
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影响因子：
64.8
作者：
Fox, PT;Ingham, RJ;Lancaster, JL
通讯作者：
Lancaster, JL
影响因子：
3.3
作者：
Chang, LC;Jones, DK;Pierpaoli, C
通讯作者：
Pierpaoli, C
影响因子：
5.7
作者：
Chang SE;Kenney MK;Loucks TM;Ludlow CL
通讯作者：
Ludlow CL
影响因子：
9.9
作者：
Foundas, AL;Corey, DM;Heilman, KM
通讯作者：
Heilman, KM
DOI：
10.1523/jneurosci.4184-08.2009
发表时间：
2009-02-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Chiang MC;Barysheva M;Shattuck DW;Lee AD;Madsen SK;Avedissian C;Klunder AD;Toga AW;McMahon KL;de Zubicaray GI;Wright MJ;Srivastava A;Balov N;Thompson PM
通讯作者：
Thompson PM