Visualization of growth factor receptor sites in rat forebrain
Visualization of growth factor receptor sites in rat forebrain
复制标题
大鼠前脑生长因子受体位点的可视化
作者：
R. Quirion;D. Araujo;N. Nair;J. Chabot
It is now known that various growth factors may also act in the central nervous system. Among them, it has recently been shown that epidermal growth factor (EGF) and insulin‐like growth factor I (IGF‐I) may possess trophic effects in the mammalian brain. We report here on the respective autoradiographic distribution of [125I]EGF and [125I]IGF‐I receptor binding sites in the rat brain, both during ontogeny and in adulthood. It appears that [125I]IGF‐I sites are more widely distributed both during ontogeny and in adulthood. These results reveal the plasticity of the expression of EGF and IGF‐I receptor sites in the mammalian brain. This could be relevant for the respective role of these two growth factors in the development and maintenance of neuronal function.
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影响因子：
56.9
作者：
R. Morrison;H. Kornblum;F. Leslie;R. Bradshaw
通讯作者：
R. Morrison;H. Kornblum;F. Leslie;R. Bradshaw
影响因子：
56.9
作者：
T. Large;S. Bodary;D. Clegg;G. Weskamp;U. Otten;L. Reichardt
通讯作者：
T. Large;S. Bodary;D. Clegg;G. Weskamp;U. Otten;L. Reichardt
影响因子：
56.9
作者：
KROMER, LF
通讯作者：
KROMER, LF
成纤维细胞生长因子促进分离的海马神经元的存活并增强神经突的延伸。
DOI：
10.1073/pnas.83.9.3012
发表时间：
1986
影响因子：
11.1
作者：
Walicke,P;Cowan,WM;Ueno,N;Baird,A;Guillemin,R
通讯作者：
Guillemin,R
生长激素过量和缺乏对下丘脑生长抑素含量和释放以及组织生长抑素分布的影响。
影响因子：
4.8
作者：
Berelowitz,M;Firestone,SL;Frohman,LA
通讯作者：
Frohman,LA