Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor

Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor
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七少膜结合配体与七少酪氨酸激酶受体的相互作用

DOI:
10.1016/0962-8924(91)90026-6
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发表时间:
1991
期刊:
影响因子:
64.8
通讯作者:
S. L. Zipursky
S. L. Zipursky
中科院分区:
综合性期刊1区
文献类型:
--
作者:
H. Krämer;Ross L. Cagan;S. L. Zipursky

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在果蝇的发育过程中,R8感光神经元诱导邻近细胞承担R7细胞的命运。遗传数据表明,诱导是由sevenlessa和sevenlessa编码的两种跨膜蛋白介导的。这两种蛋白之间的直接相互作用被表达它们的细胞系的异型聚集所证实。在发育中的眼睛中,R7前体细胞对7 - less依赖性的内化为这两种蛋白在体内的直接相互作用提供了证据。
During development of theDrosophilaretina, the R8 photoreceptor neuron induces a neighbouring cell to assume an R7 cell fate. Genetic data suggest that the induction is mediated by two transmem-brane proteins encoded bybride of sevenlessandsevenless. A direct interaction between these two proteins was demonstrated by the heterotypic aggregation of cell lines expressing them. In the developing eye the sevenless-dependent internalization of bride of sevenless by the R7 precursor cell provides evidence for a direct interaction between these two proteinsin vivo.
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