Soft, Conductive, Brain-Like, Coatings at Tips of Microelectrodes Improve Electrical Stability under Chronic, In Vivo Conditions.
Soft, Conductive, Brain-Like, Coatings at Tips of Microelectrodes Improve Electrical Stability under Chronic, In Vivo Conditions.
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微电极尖端的柔软、导电、类脑涂层可改善慢性体内条件下的电稳定性。
DOI：
10.3390/mi12070761
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发表时间：
2021-06-28
期刊：
影响因子：
3.4
通讯作者：
Muthuswamy J
中科院分区：
文献类型：
--
作者：
Sridharan A;Muthuswamy J
最近的几项研究报道了弹性模量从10s kPa到数百MPa的软神经界面改善的组织学和电生理结果。然而，许多这些软接口使用定制的制造过程。我们验证了一种易于采用的制造工艺，即仅在微电极的尖端涂覆软脑状材料（弹性模量为~5 kPa），可以改善神经界面的长期电学性能。将常规钨微电极（9个软涂层组和6个未涂层组）和Pt/Ir微电极（16个软涂层组）植入6只动物体内，时间从5周到1年多不等。采用电化学阻抗谱法评价慢性条件下脑组织-电极界面的质量。评估神经记录的单位活动和信号质量。与未涂覆的控制电极相比，涂有软硅树脂涂层的电极在6周至10年内表现出相对稳定的电阻抗特性。在6-7周内，与未涂膜的对照组相比，涂膜电极记录的单单位活动显示出更大的峰对峰振幅和可检测神经元数量的增加。我们证明了使用易于翻译的过程来创建类脑软接口的可行性，这种软接口可以潜在地克服与慢性刚性神经接口相关的可变性能。
Several recent studies have reported improved histological and electrophysiological outcomes with soft neural interfaces that have elastic moduli ranging from 10 s of kPa to hundreds of MPa. However, many of these soft interfaces use custom fabrication processes. We test the hypothesis that a readily adoptable fabrication process for only coating the tips of microelectrodes with soft brain-like (elastic modulus of ~5 kPa) material improves the long-term electrical performance of neural interfaces. Conventional tungsten microelectrodes (n = 9 with soft coatings and n = 6 uncoated controls) and Pt/Ir microelectrodes (n = 16 with soft coatings) were implanted in six animals for durations ranging from 5 weeks to over 1 year in a subset of rats. Electrochemical impedance spectroscopy was used to assess the quality of the brain tissue–electrode interface under chronic conditions. Neural recordings were assessed for unit activity and signal quality. Electrodes with soft, silicone coatings showed relatively stable electrical impedance characteristics over 6 weeks to >1 year compared to the uncoated control electrodes. Single unit activity recorded by coated electrodes showed larger peak-to-peak amplitudes and increased number of detectable neurons compared to uncoated controls over 6–7 weeks. We demonstrate the feasibility of using a readily translatable process to create brain-like soft interfaces that can potentially overcome variable performance associated with chronic rigid neural interfaces.
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影响因子：
4
作者：
Barrese JC;Aceros J;Donoghue JP
通讯作者：
Donoghue JP
影响因子：
4
作者：
Chestek CA;Gilja V;Nuyujukian P;Foster JD;Fan JM;Kaufman MT;Churchland MM;Rivera-Alvidrez Z;Cunningham JP;Ryu SI;Shenoy KV
通讯作者：
Shenoy KV
基于层状硅的慢性植入平面硅探针的机械故障模式，用于层流记录。
影响因子：
14
作者：
Kozai, Takashi D. Y.;Catt, Kasey;Li, Xia;Gugel, Zhannetta V.;Olafsson, Valur T.;Vazquez, Alberto L.;Cui, X. Tracy
通讯作者：
Cui, X. Tracy
影响因子：
3.4
作者：
Hess-Dunning A;Tyler DJ
通讯作者：
Tyler DJ
影响因子：
4.6
作者：
Das, R.;Gandhi, D.;Rousche, P. J.
通讯作者：
Rousche, P. J.