Increased intrinsic excitability and decreased synaptic inhibition in aged somatosensory cortex pyramidal neurons.
Increased intrinsic excitability and decreased synaptic inhibition in aged somatosensory cortex pyramidal neurons.
复制标题
在老化的体感皮层锥体神经元中，内在兴奋性增加和突触抑制作用降低。
DOI：
10.1016/j.neurobiolaging.2020.10.007
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发表时间：
2021-03
影响因子：
4.2
通讯作者：
Mostany R
中科院分区：
文献类型：
--
作者：
Popescu IR;Le KQ;Ducote AL;Li JE;Leland AE;Mostany R
感觉运动能力在老年时下降，部分原因是躯体感觉敏锐度的缺陷。皮质感受野扩大被认为有助于躯体感觉缺陷，并提示初级躯体感觉皮质（S1）锥体神经元的兴奋性增加或抑制性输入减少。为了确定兴奋性和抑制性的变化，我们测量了年轻和老年小鼠脑切片中触须S1神经元的两种特性。由于适应和非适应神经元-第5层（L5）中的主要锥体类型-在内在特性和抑制输入方面不同，我们根据神经元类型确定了年龄依赖性变化。我们发现，在适应神经元的内在兴奋性的年龄依赖性增加，引起的动作电位（AP）阈值下降。令人惊讶的是，在非适应性神经元中，我们发现输入电阻增加导致兴奋性增加，突触抑制减少。尖峰频率的适应，已经小的非适应神经元，进一步减少老化，而下垂，Ih的表现，增加。因此，老化引起小鼠L5的抑制性降低和内在兴奋性增加，但这些效应是锥体神经元类型所特有的。
Sensorimotor performance declines during advanced age, in part due to deficits in somatosensory acuity. Cortical receptive field expansion is thought to contribute to somatosensory deficits and is suggestive of increased excitability or decreased inhibitory inputs in pyramidal neurons of the primary somatosensory cortex (S1). To ascertain changes in excitability and inhibition, we measured both properties in neurons from vibrissal S1 in brain slices from young and aged mice. Because adapting and non-adapting neurons – the principal pyramidal types in layer 5 (L5) – differ in intrinsic properties and inhibitory inputs, we determined age-dependent changes according to neuron type. We found an age-dependent increase in intrinsic excitability in adapting neurons, caused by a decrease in action potential (AP) threshold. Surprisingly, in non-adapting neurons we found both an increase in excitability caused by increased input resistance, and a decrease in synaptic inhibition. Spike frequency adaptation, already small in non-adapting neurons, was further reduced by aging, whereas sag, a manifestation of Ih, was increased. Therefore, aging caused both a decrease in inhibition and an increase in intrinsic excitability in the murine L5, but these effects were specific to pyramidal neuron type.
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