Recovery of auditory evoked response attentional gain modulation following the first psychotic episode indexes improvements in symptom severity.
Recovery of auditory evoked response attentional gain modulation following the first psychotic episode indexes improvements in symptom severity.
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DOI：
10.1002/hbm.26306
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发表时间：
2023-06-15
影响因子：
4.8
通讯作者：
Salisbury, Dean F.
中科院分区：
文献类型：
--
作者：
Coffman, Brian A.;Curtis, Mark T.;Sklar, Alfredo;Seebold, Dylan;Salisbury, Dean F.
首发精神病 (FEP) 患者对听觉 N100/M100 增益的注意力控制能力降低。听觉感觉活动执行调节的持续问题可能会影响精神病的多个方面。作为我们之前报告听觉皮层注意力 M100 增益调制缺陷的后续工作，我们纵向检查了 M100 增益调制的变化，并进一步检查了听觉 M100 与精神病症状之间的关系。我们比较了 21 名 FEP 和 29 名匹配的健康参与者以及相隔 220±100 天的时间点之间的听觉感觉皮层的听觉 M100。在一项奇怪的听觉任务中，参与者交替注意或忽略音调，记录脑磁图数据。 M100 被测量为刺激后 80-140 毫秒双侧听觉皮层内源局部诱发反应的平均值。使用 PANSS 和 PSYRATS 评估症状。随着时间的推移，FEP 的 M100 振幅、M100 振幅的注意力调节以及症状严重程度均有所改善。此外，M100 调节的改善与阴性症状 (PANSS) 以及幻觉的身体、认知和情感成分 (PSYRATS) 的改善相关。相反，M100 整体大小的改善，而不是主动和被动 M100 振幅之间的差异，与阳性症状 (PANSS) 和幻觉的身体成分的恶化有关。结果表明 FEP 中的症状（特别是幻听）与听觉皮层神经生理学之间存在联系，其中听觉注意力和听觉感觉与症状变化呈相反关系。这些发现可能为当前的精神病病因模型提供信息，并为早期干预提供非药物途径。使用脑磁图 (MEG) 对首发精神病 (FEP) 个体和健康对照组的听觉 N100/M100 增益的注意力控制进行评估。随着时间的推移，FEP 的 M100 振幅、M100 振幅的注意力调节以及症状严重程度均有所改善。此外，M100 调节的改善与阴性症状 (PANSS) 以及幻觉的身体、认知和情感成分 (PSYRATS) 的改善相关。结果表明 FEP 中的症状（特别是幻听）与听觉皮层神经生理学之间存在联系，其中听觉注意力和听觉感觉与症状变化呈相反关系。
Attentional control of auditory N100/M100 gain is reduced in individuals with first‐episode psychosis (FEP). Persistent problems with executive modulation of auditory sensory activity may impact multiple aspects of psychosis. As a follow‐up to our prior work reporting deficits in attentional M100 gain modulation in auditory cortex, we examined changes in M100 gain modulation longitudinally, and further examined relationships between auditory M100 and symptoms of psychosis. We compared auditory M100 in auditory sensory cortex between 21 FEP and 29 matched healthy participants and between timepoints separated by 220 ± 100 days. Magnetoencephalography data were recorded while participants alternately attended or ignored tones in an auditory oddball task. M100 was measured as the average of 80–140 ms post‐stimulus in source‐localized evoked responses within bilateral auditory cortex. Symptoms were assessed using the PANSS and PSYRATS. M100 amplitudes, attentional modulation of M100 amplitudes, and symptom severity all improved in FEP over time. Further, improvement in M100 modulation correlated with improvements in negative symptoms (PANSS) as well as physical, cognitive, and emotional components of hallucinations (PSYRATS). Conversely, improvements in the overall size of the M100, rather than the difference between active and passive M100 amplitudes, were related to worsening of positive symptoms (PANSS) and physical components of hallucinations. Results indicate a link between symptoms (particularly auditory hallucinations) and auditory cortex neurophysiology in FEP, where auditory attention and auditory sensation have opposed relationships to symptom change. These findings may inform current models of psychosis etiology and could provide nonpharmaceutical avenues for early intervention. Attentional control of auditory N100/M100 gain was assessed in individuals with first‐episode psychosis (FEP) and healthy controls using magnetoencephalography (MEG). M100 amplitudes, attentional modulation of M100 amplitudes, and symptom severity all improved in FEP over time. Further, improvement in M100 modulation correlated with improvements in negative symptoms (PANSS) as well as physical, cognitive, and emotional components of hallucinations (PSYRATS). Results indicate a link between symptoms (particularly auditory hallucinations) and auditory cortex neurophysiology in FEP, where auditory attention and auditory sensation have opposed relationships to symptom change.
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影响因子：
3.4
作者：
Ren, Xi;Fribance, Sarah N.;Coffman, Brian A.;Salisbury, Dean F.
通讯作者：
Salisbury, Dean F.
影响因子：
4.5
作者：
Hugdahl, Kenneth;Nygard, Merethe;Loberg, Else-Marie
通讯作者：
Loberg, Else-Marie
影响因子：
3.2
作者：
Uusitalo, MA;Ilmoniemi, RJ
通讯作者：
Ilmoniemi, RJ
精神分裂症和双相情感障碍中重叠的听觉 M100 和 M200 异常：一项 MEG 研究
影响因子：
4.5
作者：
Wang, Ying;Jia, Yanbin;Huang, Li
通讯作者：
Huang, Li
影响因子：
10.6
作者：
Ethridge, Lauren E.;Hamm, Jordan P.;Shapiro, John R.;Summerfelt, Ann T.;Keedy, Sarah K.;Stevens, Michael C.;Pearlson, Godfrey;Tamminga, Carol A.;Boutros, Nash N.;Sweeney, John A.;Keshavan, Matcheri S.;Thaker, Gunvant;Clementz, Brett A.
通讯作者：
Clementz, Brett A.