Diverse stem cells for periodontal tissue formation and regeneration.
Diverse stem cells for periodontal tissue formation and regeneration.
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DOI：
10.1002/dvg.23495
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发表时间：
2022-09
期刊：
影响因子：
1.5
通讯作者：
Ono, Wanida
中科院分区：
文献类型：
--
作者：
Nagata, Mizuki;English, Jeryl D.;Ono, Noriaki;Ono, Wanida
牙周组织由多个矿化和非矿化组织单元组成，包括牙根表面上的牙骨质、牙槽骨、牙周韧带（PDL）和牙龈。PDL含有多种细胞群，包括称为PDLSC的间充质干/祖细胞（MSC），其有助于牙周再生。最近利用小鼠遗传模型的研究揭示了这些间充质祖细胞在其天然环境中的身份，特别是关于它们如何有助于牙周组织的稳态和修复。目前的概念是PDL中的间充质祖细胞定位于血管周围的小生境。单细胞RNA测序（scRNA-seq）分析揭示了牙周组织中细胞的异质性和细胞类型特异性标志物，以及它们与牙囊中前体细胞的发育关系。PDLSC的特征及其在体内的多样性现在开始被解开，这要归功于小鼠遗传模型和scRNA-seq分析的见解，这有助于揭示人类PDL中干细胞的基本特性。这些新的知识将是非常重要的开发更有效的干细胞为基础的再生疗法，以修复牙周组织在未来。
The periodontium is comprised of multiple units of mineralized and non-mineralized tissues including the cementum on the root surface, the alveolar bone, periodontal ligament (PDL), and the gingiva. PDL contains a variety of cell populations including mesenchymal stem/progenitor cells (MSCs) termed PDLSCs, which contribute to periodontal regeneration. Recent studies utilizing mouse genetic models shed light on the identities of these mesenchymal progenitors in their native environment, particularly regarding how they contribute to homeostasis and repair of the periodontium. The current concept is that mesenchymal progenitors in the PDL are localized to the perivascular niche. Single-cell RNA sequencing (scRNA-seq) analyses reveal heterogeneity and cell-type specific markers of cells in the periodontium, as well as their developmental relationship with precursor cells in the dental follicle. The characteristics of PDLSCs and their diversity in vivo are now beginning to be unraveled thanks to insights from mouse genetic models and scRNA-seq analyses, which aid to uncover the fundamental properties of stem cells in the human PDL. The new knowledge will be highly important for developing more effective stem cell-based regenerative therapies to repair periodontal tissues in the future.
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