Repeated Acquisition in the Morris Swim Task: Effects of MDMA, Methamphetamine and Methylphenidate.
Repeated Acquisition in the Morris Swim Task: Effects of MDMA, Methamphetamine and Methylphenidate.
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DOI：
10.1007/s40732-014-0023-1
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发表时间：
2014-06-01
影响因子：
1.3
通讯作者：
April, L. Brooke
中科院分区：
文献类型：
--
作者：
Galizio, Mark;Byrd, Bridget D.;Robinson, Andrea M.;Hawkey, Andrew;Rayburn-Reeves, Rebecca;April, L. Brooke
急性效应的亚甲二氧基甲基苯丙胺（MDMA），甲基苯丙胺（MA）和哌甲酯（MPD）进行了研究，使用受试者内，重复采集/性能程序适应莫里斯游泳任务。为了研究位置学习，采集组件包括一个隐藏的平台，在不同的实验会话的位置。作为对非特定于采集的药物效应的对照，包括性能组分，其中隐藏平台在每个实验阶段中处于相同的合并位置。所有三种药物都以剂量依赖性方式增加了逃避潜伏期和游泳距离。然而，在获取组件中的损伤通常仅在也产生性能组件损伤的剂量下观察到，这表明效果对学习位置没有选择性。在任何剂量下，这些药物都没有产生学习或表现的增强。两者合计，结果表明，急性暴露于这些精神兴奋剂产生的性能在莫里斯任务的全球性损害，而不是特定的赤字在地方学习。
Acute effects of methylenedioxymethamphetamine (MDMA), methamphetamine (MA) and methylphenidate (MPD) were studied using a within-subject, repeated acquisition/performance procedure adapted to the Morris Swim Task. To investigate place learning, the acquisition component consisted of a hidden platform that varied in location across experimental sessions. As a control for drug effects not specific to acquisition, a performance component was included in which the hidden platform was in the same pool location in every experimental session. All three drugs increased escape latencies and swim distances in dose-dependent fashion. However, impairment in the acquisition component was generally observed only at doses that also produced impairment in the performance component, suggesting that effects were not selective to place learning. None of the drugs produced enhancement of learning or performance at any dose. Taken together, the results suggest that acute exposure to these psychomotor stimulants produce global impairment of performance in the Morris task, rather than specific deficits in place learning.
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DOI：
10.1016/j.pbb.2009.09.010
发表时间：
2009-12
期刊：
Pharmacology, biochemistry, and behavior
影响因子：
--
作者：
Galizio M;McKinney P;Cerutti DT;Pitts RC
通讯作者：
Pitts RC
影响因子：
3.4
作者：
HANDLEY, GW;CALHOUN, WH
通讯作者：
CALHOUN, WH
影响因子：
1.9
作者：
Harper, DN;Wisnewski, R;Schenk, S
通讯作者：
Schenk, S
影响因子：
6
作者：
Baicy, Kate;London, Edythe D.
通讯作者：
London, Edythe D.
影响因子：
2.3
作者：
McCann, Una D.;Kuwabara, Hiroto;Ricaurte, George A.
通讯作者：
Ricaurte, George A.