Lateral entorhinal cortex is necessary for associative but not nonassociative recognition memory.
Lateral entorhinal cortex is necessary for associative but not nonassociative recognition memory.
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DOI：
10.1002/hipo.22165
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发表时间：
2013-12
期刊：
影响因子：
3.5
通讯作者：
Ainge, James A.
中科院分区：
文献类型：
--
作者：
Wilson, David I. G.;Watanabe, Sakurako;Milner, Helen;Ainge, James A.
外侧内嗅皮层（LEC）提供了两个主要的输入途径之一，海马和已被建议处理的非空间情景记忆的细节。结合来自内侧内嗅皮层的空间信息，假设这种上下文信息用于在海马体中形成整合的空间选择性、上下文特异性反应，这是情景记忆的基础。最近，我们报道了LEC是识别在特定背景下经历的物体所必需的（Wilson等人（2013）Hippocampus 23：352-366）。在这里，我们试图扩展这项工作，以评估LEC在识别一个事件中的对象，地点和上下文的所有关联组合中的作用。与对照组不同，LEC兴奋性毒性病变的大鼠没有表现出识别熟悉的物体组合的证据，在上下文中的地方，或物体的地方和上下文。然而，LEC损伤大鼠表现出正常的识别对象和地方相互独立（非联想识别）。与我们以前的研究结果一起，这些数据表明LEC对于联想识别记忆至关重要，并且可以将与情景记忆形成所需的对象，地点和上下文相关的信息结合在一起。
The lateral entorhinal cortex (LEC) provides one of the two major input pathways to the hippocampus and has been suggested to process the nonspatial contextual details of episodic memory. Combined with spatial information from the medial entorhinal cortex it is hypothesised that this contextual information is used to form an integrated spatially selective, context-specific response in the hippocampus that underlies episodic memory. Recently, we reported that the LEC is required for recognition of objects that have been experienced in a specific context (Wilson et al. (2013) Hippocampus 23:352-366). Here, we sought to extend this work to assess the role of the LEC in recognition of all associative combinations of objects, places and contexts within an episode. Unlike controls, rats with excitotoxic lesions of the LEC showed no evidence of recognizing familiar combinations of object in place, place in context, or object in place and context. However, LEC lesioned rats showed normal recognition of objects and places independently from each other (nonassociative recognition). Together with our previous findings, these data suggest that the LEC is critical for associative recognition memory and may bind together information relating to objects, places, and contexts needed for episodic memory formation.
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