Resting metabolic activity in the cingulate cortex and vulnerability to posttraumatic stress disorder.
Resting metabolic activity in the cingulate cortex and vulnerability to posttraumatic stress disorder.
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DOI：
10.1001/archgenpsychiatry.2009.138
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发表时间：
2009-10
影响因子：
--
通讯作者：
Pitman, Roger K.
中科院分区：
文献类型：
--
作者：
Shin, Lisa M.;Lasko, Natasha B.;Macklin, Michael L.;Karpf, Rachel D.;Milad, Mohammed R.;Orr, Scott P.;Goetz, Jared M.;Fischman, Alan J.;Rauch, Scott L.;Pitman, Roger K.
最近的神经影像研究发现，创伤后应激障碍(PTSD)患者的前扣带回皮质、杏仁核和海马区功能异常。以确定在创伤后应激障碍中发现的静息功能异常是获得性特征还是家族危险因素。横断面设计包括同卵双胞胎，创伤暴露不协调。学术医学中心。有创伤后应激障碍的退伍军人(n=14)和他们的同卵双胞胎(n=14)，以及有战斗接触但没有创伤后应激障碍的退伍军人(n=19)和他们的相同的、不暴露在战斗中的同卵双胞胎(n=19)。我们使用正电子发射断层扫描和[18F]-氟代脱氧葡萄糖来检测静息状态下大脑局部葡萄糖代谢率(RCMRglu)。患有创伤后应激障碍的退伍军人及其同卵双生子的背侧前扣带回/中扣带回的静息rCMRglu显著高于非创伤后应激障碍退伍军人及其同卵双生子。未暴露在战斗中的同卵双胞胎的dACC/MCC中的rCMRglu与战斗暴露严重程度、创伤后应激障碍症状严重程度和双胞胎中的酒精使用呈正相关。DACC/MCC静息代谢活动增强似乎是暴露于心理创伤后发展为创伤后应激障碍的家族危险因素。
Recent neuroimaging research has revealed functional abnormalities in the anterior cingulate cortex, amygdala and hippocampus in posttraumatic stress disorder (PTSD). To determine whether resting functional abnormalities found in PTSD are acquired characteristics or familial risk factors. Cross-sectional design including identical twins discordant for trauma exposure. Academic medical center. Combat-exposed veterans with PTSD (n=14) and their identical, combat-unexposed co-twins (n=14), as well as combat-exposed veterans without PTSD (n=19) and their identical, combat-unexposed co-twins (n=19). We used positron emission tomography and [18F]-fluorodeoxyglucose to examine resting regional cerebral metabolic rates for glucose (rCMRglu). Veterans with PTSD and their co-twins had significantly higher resting rCMRglu in dorsal anterior cingulate/mid cingulate cortex (dACC/MCC) compared to non-PTSD veterans and their co-twins. Resting rCMRglu in dACC/MCC in the combat-unexposed co-twins was positively correlated with combat exposure severity, PTSD symptom severity, and alcohol use in their exposed twins. Enhanced resting metabolic activity in dACC/MCC appears to represent a familial risk factor for developing PTSD after exposure to psychological trauma.
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