The complexity of virus systems: the case of endosymbionts.

The complexity of virus systems: the case of endosymbionts.
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DOI:
10.1016/j.mib.2012.04.010
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发表时间:
2012-08
影响因子:
5.4
通讯作者:
Bordenstein SR
Bordenstein SR
中科院分区:
生物学2区
文献类型:
--
作者:
Metcalf JA;Bordenstein SR

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宿主-微生物共生包括细菌内共生,是地球上一些最亲密、最持久的相互作用。虽然由于细胞内生活方式的限制,基因流动可能会受到限制,但许多内共生菌,特别是那些转换宿主的内共生菌,到处都是可移动的DNA和噬菌体。一种内共生体,沃尔巴克氏体(Wolbachia pipientis),感染大量节肢动物和线虫物种,其基因组中通常有很大一部分专门用于一种名为WO的病毒的前噬菌体序列。这种噬菌体挑战了噬菌体和内共生体进化的基本理论,即噬菌体模块理论和专性细胞内物种的细菌基因组稳定性。WO也为病毒、细菌和真核生物之间的三方相互作用打开了令人兴奋的窗口。
Host-microbe symbioses involving bacterial endosymbionts comprise some of the most intimate and long-lasting interactions on the planet. While restricted gene flow might be expected due to their intracellular lifestyle, many endosymbionts, especially those that switch hosts, are rampant with mobile DNA and bacteriophages. One endosymbiont, Wolbachia pipientis, infects a vast number of arthropod and nematode species and often has a significant portion of its genome dedicated to prophage sequences of a virus called WO. This phage has challenged fundamental theories of bacteriophage and endosymbiont evolution, namely the phage Modular Theory and bacterial genome stability in obligate intracellular species. WO has also opened up exciting windows into the tripartite interactions between viruses, bacteria, and eukaryotes.
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