Multimodal profiling of term human decidua demonstrates immune adaptations with pregravid obesity.
Multimodal profiling of term human decidua demonstrates immune adaptations with pregravid obesity.
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DOI：
10.1016/j.celrep.2023.112769
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发表时间：
2023-07-25
期刊：
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
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孕早期母胎界面的白细胞多样性已被广泛描述，然而，术语蜕膜的免疫学景观仍然知之甚少。因此，我们分析了人类白细胞从足月蜕膜收集通过计划剖宫产。相对于前三个月，我们的分析显示从NK细胞和巨噬细胞到T细胞的转变和增强的免疫激活。虽然循环和蜕膜T细胞的表型不同，他们表现出显着的克隆型共享。我们还报告了蜕膜巨噬细胞内的显著多样性，其频率与妊娠前母体体重指数呈正相关。有趣的是，蜕膜巨噬细胞对细菌配体的反应能力随着妊娠前肥胖而降低，这表明免疫调节可能是保护胎儿免受母体过度炎症的一种机制。这些发现是未来研究损害胎儿健康和生殖成功的病理条件的资源。Sureshchandra等人描述了与妊娠早期相比，妊娠晚期胎盘中蜕膜免疫景观的变化，以及蜕膜组织中免疫调节机制的建立，作为保护胎儿免受肥胖诱导的母体炎症的机制。
Leukocyte diversity of the first-trimester maternal-fetal interface has been extensively described; however, the immunological landscape of the term decidua remains poorly understood. We therefore profiled human leukocytes from term decidua collected via scheduled cesarean delivery. Relative to the first trimester, our analyses show a shift from NK cells and macrophages to T cells and enhanced immune activation. Although circulating and decidual T cells are phenotypically distinct, they demonstrate significant clonotype sharing. We also report significant diversity within decidual macrophages, the frequency of which positively correlates with pregravid maternal body mass index. Interestingly, the ability of decidual macrophages to respond to bacterial ligands is reduced with pregravid obesity, suggestive of skewing toward immunoregulation as a possible mechanism to safeguard the fetus against excessive maternal inflammation. These findings are a resource for future studies investigating pathological conditions that compromise fetal health and reproductive success. Sureshchandra et al. describe the changes in the decidual immune landscape in the third-trimester placenta compared with early pregnancy and the establishment of immunoregulatory mechanisms in decidual tissues as a mechanism of fetal protection from obesity-induced maternal inflammation.
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DOI：
10.1111/j.1600-0897.2004.00156.x
发表时间：
2004-04-01
影响因子：
3.6
作者：
Abrahams, VM;Kim, YM;Mor, G
通讯作者：
Mor, G
影响因子：
7.3
作者：
Gaynor LM;Colucci F
通讯作者：
Colucci F
影响因子：
15.3
作者：
Ashkar, A A;Di Santo, J P;Croy, B A
通讯作者：
Croy, B A
影响因子：
8.3
作者：
Gaillard, Romy;Steegers, Eric A. P.;Jaddoe, Vincent W. V.
通讯作者：
Jaddoe, Vincent W. V.
DOI：
10.4049/jimmunol.1003153
发表时间：
2011-02-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Houser BL;Tilburgs T;Hill J;Nicotra ML;Strominger JL
通讯作者：
Strominger JL