Antibacterial activity of a modified unfilled resin containing a novel polymerizable quaternary ammonium salt MAE-HB.
Antibacterial activity of a modified unfilled resin containing a novel polymerizable quaternary ammonium salt MAE-HB.
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含有新型可聚合季铵盐MAE-HB的改性未填充树脂的抗菌活性
DOI：
10.1038/srep33858
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发表时间：
2016-09-23
影响因子：
4.6
通讯作者：
Chen JH
中科院分区：
文献类型：
--
作者：
Huang L;Yu F;Sun X;Dong Y;Lin PT;Yu HH;Xiao YH;Chai ZG;Xing XD;Chen JH
具有强大和持久抗菌性能的树脂对于预防继发性龋齿至关重要。本研究评价了一种含有2-甲基丙烯酰氧乙基十六烷基甲基溴化铵（MAE-HB）的无填料树脂对变形链球菌UA 159（S. mutansUA 159）。将MAE-HB以10质量%添加到未填充树脂中，并且将不含MAE-HB的未填充树脂用作对照。10% MAE-HB未填充树脂在1、7、30、180 d对细菌生长有明显抑制作用（P < 0.05）。生长抑制作用与孵育时间无关（P > 0.05）。在任何时间点，对照与10%-MAE-HB未填充树脂洗脱液的抗菌活性均无显著差异（P > 0.05）。10%-MAE-HB未填充树脂上的细菌数量明显低于对照。Fe-SEM和CLSM显示10%-MAE-HB未填充树脂破坏了细菌细胞的完整性。在10%-MAE-HB未填充树脂上，细菌葡萄糖基转移酶gtfBandgtfC的表达低于对照（P < 0.05）。这些数据表明，MAE-HB的掺入赋予未填充树脂对S具有强而持久的抗菌效果。变异体
Resins with strong and long-lasting antibacterial properties are critical for the prevention of secondary dental caries. In this study, we evaluated the antibacterial effect and the underlying mechanism of action of an unfilled resin incorporating 2-methacryloxylethyl hexadecyl methyl ammonium bromide (MAE-HB) againstStreptococcus mutansUA159 (S. mutansUA159). MAE-HB was added into unfilled resin at 10 mass%, and unfilled resin without MAE-HB served as the control. Bacterial growth was inhibited on 10%-MAE-HB unfilled resin compared with the control at 1 d, 7 d, 30 d, or 180 d (P < 0.05). The growth inhibitory effect was independent of the incubation time (P > 0.05). No significant differences in the antibacterial activities of eluents from control versus 10%-MAE-HB unfilled resins were observed at any time point (P > 0.05). The number of bacteria attached to 10%-MAE-HB unfilled resin was considerably lower than that to control. Fe-SEM and CLSM showed that 10%-MAE-HB unfilled resin disturbed the integrity of bacterial cells. Expression of the bacterial glucosyltransferases,gtfBandgtfC, was lower on 10%-MAE-HB unfilled resin compared to that on control (P < 0.05). These data indicate that incorporation of MAE-HB confers unfilled resin with strong and long-lasting antibacterial effects againstS. mutans.
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影响因子：
5
作者：
Cury, Jaime Aparecido;de Oliveira, Branca Heloisa;Andalo Tenuta, Livia Maria
通讯作者：
Andalo Tenuta, Livia Maria
影响因子：
5
作者：
Jandt, Klaus D.;Sigusch, Bernd W.
通讯作者：
Sigusch, Bernd W.
影响因子：
14
作者：
Imazato, S;Ebi, N;Ebisu, S
通讯作者：
Ebisu, S
掺入新型可聚合季铵盐MAE-DB的树脂对变形链球菌的抗菌作用
DOI：
10.1002/jbm.b.32703
发表时间：
2012-07-01
影响因子：
3.4
作者：
Huang, Li;Sun, Xiang;Chen, Ji-Hua
通讯作者：
Chen, Ji-Hua
DOI：
10.1016/j.jmbbm.2015.10.028
发表时间：
2016-03-01
影响因子：
3.9
作者：
Huang, Qi-ting;He, Jing-wei;Vallittu, Pekka K.
通讯作者：
Vallittu, Pekka K.