Brain structural co-development is associated with internalizing symptoms two years later in the ABCD cohort.
Brain structural co-development is associated with internalizing symptoms two years later in the ABCD cohort.
复制标题
DOI：
10.1556/2006.2023.00006
复制
发表时间：
2023-03-30
影响因子：
7.8
通讯作者：
Potenza, Marc N.
中科院分区：
文献类型：
--
作者：
Zhao, Yihong;Paulus, Martin P.;Potenza, Marc N.
关键词：
大约 1/3 的青少年每天花四个小时以上参与屏幕媒体活动 (SMA)。这项研究利用纵向脑成像和中介分析来检查 SMA、大脑模式和内化问题之间的关系。对来自青少年大脑认知发展 (ABCD) 参与者的数据进行了分析，这些参与者具有通过质量控制的基线和两年随访结构成像数据（N = 5,166；2,385 名女孩）。联合和个体变异解释 (JIVE) 确定了 221 个大脑特征之间的大脑共同发育模式（即基线和两年随访数据之间表面积、厚度或皮质和皮质下灰质体积的差异）。广义线性混合效应模型在两年的随访中研究了基线 SMA、结构共同发展以及内化和外化精神病理学之间的关联。基线时的 SMA 与第 2 年的内化精神病理学 () 和结构性共同发育模式 () 相关，其中共同发育模式表明，脑干灰质体积、双侧上额叶、头侧中额叶、顶下和颞下区域的灰质体积和/或皮质厚度测量值的变化率比其他区域更相似。该成分部分介导了基线 SMA 与未来内化问题之间的关系（间接效应 = 0.020，P 值 = 0.043，介导比例：2.24%）。从统计数据来看，9-10 岁青少年更多地参与 SMA 预示着两年后的内化水平更高。这种关联是由皮质脑干回路介导的，尽管效应大小相对较小。这些发现可能有助于描述导致内化行为的过程，并有助于识别面临此类问题更大风险的个人。
About 1/3 of youth spend more than four hours/day engaged in screen media activity (SMA). This investigation utilized longitudinal brain imaging and mediation analyses to examine relationships among SMA, brain patterns, and internalizing problems. Data from Adolescent Brain Cognitive Development (ABCD) participants with baseline and two-year follow-up structural imaging data that passed quality control (N = 5,166; 2,385 girls) were analyzed. Joint and Individual Variation Explained (JIVE) identified a brain co-development pattern among 221 brain features (i.e., differences in surface area, thickness, or cortical and subcortical gray-matter volume between baseline and two-year-follow-up data). Generalized linear mixed-effect models investigated associations between baseline SMA, structural co-development and internalizing and externalizing psychopathology at two-year follow-up. SMA at baseline was related to internalizing psychopathology at year 2 () and a structural co-development pattern (), where the co-development pattern suggested that rates of change in gray-matter volumes of the brainstem, gray-matter volumes and/or cortical thickness measures of bilateral superior frontal, rostral middle frontal, inferior parietal, and inferior temporal regions were more similar than those in other regions. This component partially mediated the relationship between baseline SMA and future internalizing problems (indirect effect = 0.020, P-value = 0.043, proportion mediated: 2.24%). Greater youth engagement in SMA at ages 9–10 years statistically predicted higher levels of internalizing two years later. This association was mediated by cortical-brainstem circuitry, albeit with relatively small effect sizes. The findings may help delineate processes contributing to internalizing behaviors and assist in identifying individuals at greater risk for such problems.
登录
查看更多内容
DOI：
10.3390/ijerph15040668
发表时间：
2018-04-03
影响因子：
--
作者：
González-Bueso V;Santamaría JJ;Fernández D;Merino L;Montero E;Ribas J
通讯作者：
Ribas J
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
34.7
作者：
Alexander-Bloch, Aaron;Giedd, Jay N.;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
影响因子：
3.3
作者：
Bolger, KE;Patterson, CJ
通讯作者：
Patterson, CJ
影响因子：
4.6
作者：
Hicks, Brian M.;Blonigen, Daniel M.;Mcgue, Matt
通讯作者：
Mcgue, Matt