Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography.
Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography.
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DOI：
10.1001/archophthalmol.2009.145
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发表时间：
2009-07
影响因子：
--
通讯作者：
Liebmann, Jeffrey M.
中科院分区：
文献类型：
--
作者：
Wang, Min;Hood, Donald C.;Cho, Jung-Suk;Ghadiali, Quraish;De Moraes, Gustavo V.;Zhang, Xian;Ritch, Robert;Liebmann, Jeffrey M.
探讨使用频域光学相干断层扫描 (fdOCT) 和计算机辅助手动分割程序对青光眼患者视网膜神经节细胞层厚度进行局部测量的可行性。 fdOCT 扫描是从 26 名青光眼患者和 20 名对照受试者的 1 只眼睛的水平中线获得的。各层的厚度是通过计算机程序辅助的手动分割程序来测量的。根据标准自动视野检查中的中心凹敏感性，将患者分为低敏感性组和高敏感性组。低敏感组的RGC加内丛状和视网膜神经纤维层明显薄于高敏感组。虽然患者的这些层比对照组薄，但所有 3 组的内核层和受体层的厚度相似。此外，一只受青光眼影响的眼睛中视网膜神经节细胞和内丛状层的变薄与 10-2 视野敏感性的丧失具有定性的对应关系。 RGC 层厚度的局部测量可以使用手动分割程序从 fdOCT 扫描获得，这些测量显示与视野灵敏度的定性一致性。
To explore the feasibility of obtaining a local measurement of the thickness of the retinal ganglion cell layer in patients with glaucoma using frequency-domain optical coherence tomography (fdOCT) and a computer-aided manual segmentation procedure. The fdOCT scans were obtained from the horizontal midline for 1 eye of 26 patients with glaucoma and 20 control subjects. The thickness of various layers was measured with a manual segmentation procedure aided by a computer program. The patients were divided into low-and high-sensitivity groups based on their foveal sensitivity on standard automated perimetry. The RGC plus inner plexiform and the retinal nerve fiber layers of the low-sensitivity group were significantly thinner than those of the high-sensitivity group. While these layers were thinner in the patients than the controls, the thicknesses of inner nuclear layer and receptor layer were similar in all 3 groups. Further, the thinning of the retinal ganglion cell plus inner plexiform layer in 1 glaucoma-affected eye showed qualitative correspondence to the loss in 10-2 visual field sensitivity. Local measures of RGC layer thickness can be obtained from fdOCT scans using a manual segmentation procedure, and these measures show qualitative agreement with visual field sensitivity.
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