Obesity and acute stress modulate appetite and neural responses in food word reactivity task.
Obesity and acute stress modulate appetite and neural responses in food word reactivity task.
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DOI：
10.1371/journal.pone.0271915
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
肥胖可能是由于对环境食物线索的过度摄入造成的，而压力可能会导致更大的摄入量和体重。我们使用了一个新的fMRI任务来探索肥胖和压力如何影响对相对最小的食物线索（代表食物的单词，类似于黑板菜单）的食欲反应。29名成年人（16名女性，13名男性），其中17人肥胖，12人消瘦，完成了两次功能性磁共振成像扫描，一次是在社会和生理压力刺激下进行的，另一次是在对照任务下进行的。食物词反应任务评估主观的食物方法（想要）以及食物回避（约束）的反应，沿着神经反应，表示高能量密度（艾德）的食物，低艾德的食物，和非食物的话。每次扫描后，多项自由进食。肥胖组和瘦组在对食物与非食物、高ED与低ED食物词的反应中，在食欲和注意力/自我调节系统的激活方面表现出差异和相似性。在压力和非压力条件下，激活模式在很大程度上是相似的，有一些证据表明肥胖组和瘦组之间存在差异。在两种情况下，肥胖组都比瘦组吃得多。我们的研究结果表明，在压力和非压力状态下对最小食物线索的神经反应可能导致过度消费和肥胖。
Obesity can result from excess intake in response to environmental food cues, and stress can drive greater intake and body weight. We used a novel fMRI task to explore how obesity and stress influenced appetitive responses to relatively minimal food cues (words representing food items, presented similarly to a chalkboard menu). Twenty-nine adults (16F, 13M), 17 of whom had obesity and 12 of whom were lean, completed two fMRI scans, one following a combined social and physiological stressor and the other following a control task. A food word reactivity task assessed subjective food approach (wanting) as well as food avoidant (restraint) responses, along with neural responses, to words denoting high energy-density (ED) foods, low-ED foods, and non-foods. A multi-item ad-libitum meal followed each scan. The obese and lean groups demonstrated differences as well as similarities in activation of appetitive and attention/self-regulation systems in response to food vs. non-food, and to high-ED vs. low-ED food words. Patterns of activation were largely similar across stress and non-stress conditions, with some evidence for differences between conditions within both obese and lean groups. The obese group ate more than the lean group in both conditions. Our results suggest that neural responses to minimal food cues in stressed and non-stressed states may contribute to excess consumption and adiposity.
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