The Role of Astrocytic Calcium Signaling in the Aged Prefrontal Cortex.
The Role of Astrocytic Calcium Signaling in the Aged Prefrontal Cortex.
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DOI：
10.3389/fncel.2018.00379
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发表时间：
2018
影响因子：
5.3
通讯作者：
Oliveira JF
中科院分区：
文献类型：
--
作者：
Guerra-Gomes S;Viana JF;Nascimento DSM;Correia JS;Sardinha VM;Caetano I;Sousa N;Pinto L;Oliveira JF
衰老是一个终身的过程，其特征是由于大脑神经回路的结构和功能变化而导致的认知能力下降。神经元-胶质细胞信号传导是大脑回路结构和功能的基本组成部分，但其在衰老中的可能作用仍然是难以捉摸的。值得注意的是，前额叶皮层的神经元-胶质细胞网络经历了与年龄相关的改变，这些改变会影响认知功能，而胶质细胞钙信号传导的中断与认知表现有关。受这些观察结果的启发，我们探讨了胶质细胞在衰老过程中认知的可能作用，考虑星形胶质细胞缺乏IP 3R 2依赖性Ca 2+信号传导的小鼠模型。与在两次试验位置识别任务中显示出显著损伤的老年野生型动物不同，老年IP 3R 2 KO小鼠没有。考虑到前额叶皮层中的神经元和星形胶质细胞密度，显示老年IP 3R 2 KO小鼠呈现NeuN+神经元密度降低和S100β+星形胶质细胞密度增加。此外，年老的IP 3R 2 KO小鼠在该区域显示出精细的树突状树。这些发现表明星形胶质细胞在老年大脑中的新作用。对老年大脑中神经元-胶质细胞相互作用的进一步评估将揭示处理人类健康认知老化的新策略。
Aging is a lifelong process characterized by cognitive decline putatively due to structural and functional changes of neural circuits of the brain. Neuron-glial signaling is a fundamental component of structure and function of circuits of the brain, and yet its possible role in aging remains elusive. Significantly, neuron-glial networks of the prefrontal cortex undergo age-related alterations that can affect cognitive function, and disruption of glial calcium signaling has been linked with cognitive performance. Motivated by these observations, we explored the possible role of glia in cognition during aging, considering a mouse model where astrocytes lacked IP3R2-dependent Ca2+ signaling. Contrarily to aged wild-type animals that showed significant impairment in a two-trial place recognition task, aged IP3R2 KO mice did not. Consideration of neuronal and astrocytic cell densities in the prefrontal cortex, revealed that aged IP3R2 KO mice present decreased densities of NeuN+ neurons and increased densities of S100β+ astrocytes. Moreover, aged IP3R2 KO mice display refined dendritic trees in this region. These findings suggest a novel role for astrocytes in the aged brain. Further evaluation of the neuron-glial interactions in the aged brain will disclose novel strategies to handle healthy cognitive aging in humans.
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星形胶质细胞钙高程的功能作用：从突触到行为。
影响因子：
5.3
作者：
Guerra-Gomes S;Sousa N;Pinto L;Oliveira JF
通讯作者：
Oliveira JF
影响因子：
64.8
作者：
通讯作者：
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影响因子：
4.2
作者：
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通讯作者：
Svendsen, Clive N.
影响因子：
16.2
作者：
Jagust W
通讯作者：
Jagust W
影响因子：
56.9
作者：
Bindocci, Erika;Savtchouk, Iaroslav;Volterra, Andrea
通讯作者：
Volterra, Andrea