Regulation of Cholesterol Metabolism by Bioactive Components of Soy Proteins: Novel Translational Evidence.
Regulation of Cholesterol Metabolism by Bioactive Components of Soy Proteins: Novel Translational Evidence.
复制标题
DOI：
10.3390/ijms22010227
复制
发表时间：
2020-12-28
影响因子：
5.6
通讯作者：
Portincasa P
中科院分区：
文献类型：
--
作者：
Caponio GR;Wang DQ;Di Ciaula A;De Angelis M;Portincasa P
高胆固醇血症是导致全球心血管疾病风险增加的一个关键病理生理因素。控制血浆胆固醇水平和其他代谢风险因素对于预防心血管疾病相关发病率和死亡率的总体疾病负担至关重要。膳食胆固醇在小肠中经历胶束化和吸收，通过血液转运，并在肝脏中摄取。大量胆固醇来源于肝脏合成，并由肝脏分泌到胆汁中，与胆汁酸（BA）和磷脂一起形成胶束和囊泡。在临床医学中，饮食建议与药物干预一起发挥关键作用，以抵消慢性高胆固醇血症的不良影响。生物活性化合物也可能是最初饮食计划的一部分。具体来说，大豆含有对血浆胆固醇水平具有生物活性的蛋白质和肽，这种特性使大豆蛋白成为功能性食品。在这里，我们讨论了大豆蛋白如何调节脂质代谢和降低血浆胆固醇浓度，在改善代谢和血脂异常相关的条件的潜在结果。
Hypercholesterolemia represents one key pathophysiological factor predisposing to increasing risk of developing cardiovascular disease worldwide. Controlling plasma cholesterol levels and other metabolic risk factors is of paramount importance to prevent the overall burden of disease emerging from cardiovascular-disease-related morbidity and mortality. Dietary cholesterol undergoes micellization and absorption in the small intestine, transport via blood, and uptake in the liver. An important amount of cholesterol originates from hepatic synthesis, and is secreted by the liver into bile together with bile acids (BA) and phospholipids, with all forming micelles and vesicles. In clinical medicine, dietary recommendations play a key role together with pharmacological interventions to counteract the adverse effects of chronic hypercholesterolemia. Bioactive compounds may also be part of initial dietary plans. Specifically, soybean contains proteins and peptides with biological activity on plasma cholesterol levels and this property makes soy proteins a functional food. Here, we discuss how soy proteins modulate lipid metabolism and reduce plasma cholesterol concentrations in humans, with potential outcomes in improving metabolic- and dyslipidemia-related conditions.
登录
查看更多内容
DOI：
10.1136/bmj.d4488
发表时间：
2011-08-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Buitrago-Lopez A;Sanderson J;Johnson L;Warnakula S;Wood A;Di Angelantonio E;Franco OH
通讯作者：
Franco OH
影响因子：
158.5
作者：
ANDERSON, JW;JOHNSTONE, BM;COOKNEWELL, ME
通讯作者：
COOKNEWELL, ME
DOI：
10.1080/07315724.2005.10719467
发表时间：
2005-06-01
影响因子：
3.5
作者：
Anderson, JW;Hoie, LH
通讯作者：
Hoie, LH
影响因子：
6.1
作者：
Cho, Seong-Jun;Juillerat, Marcel A.;Lee, Cherl-Ho
通讯作者：
Lee, Cherl-Ho
影响因子：
15.9
作者：
ADMIRAND, WH;SMALL, DM
通讯作者：
SMALL, DM