Specific Gray Matter Volume Changes of the Brain in Unipolar and Bipolar Depression.
Specific Gray Matter Volume Changes of the Brain in Unipolar and Bipolar Depression.
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单相和双相抑郁症中大脑的特定灰质体积变化。
DOI：
10.3389/fnhum.2020.592419
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发表时间：
2020
影响因子：
2.9
通讯作者：
Sun N
中科院分区：
文献类型：
--
作者：
Wang J;Liu P;Zhang A;Yang C;Liu S;Wang J;Xu Y;Sun N
找出双相抑郁(BD)和单相抑郁(UD)的共同和独特的结构基础对临床诊断至关重要。本研究共纳入85名受试者，包括22名BD患者、36名UD患者和27名健康对照。使用基于体素的形态学方法识别灰质体积(GMV)的共性和特异性变化，以确定其结构基础。三组间GMV差异有统计学意义。与正常对照组相比，UD患者左侧额下回眼眶部分GMV降低，而BD患者左额中回GMV降低。与BD相比，UD患者左侧缘上回和颞中回GMV增加。我们的结果揭示了UD和BD患者不同的结构变化，提示BD和UD具有不同的神经生理基础。我们的研究有助于形态计量学变化的生物学测定，有助于区分UD和BD。
To identify the common and specific structural basis of bipolar depression (BD) and unipolar depression (UD) is crucial for clinical diagnosis. In this study, a total of 85 participants, including 22 BD patients, 36 UD patients, and 27 healthy controls, were enrolled. A voxel-based morphology method was used to identify the common and specific changes of the gray matter volume (GMV) to determine the structural basis. Significant differences in GMV were found among the three groups. Compared with healthy controls, UD patients showed decreased GMV in the orbital part of the left inferior frontal gyrus, whereas BD patients showed decreased GMV in the orbital part of the left middle frontal gyrus. Compared with BD, UD patients have increased GMV in the left supramarginal gyrus and middle temporal gyrus. Our results revealed different structural changes in UD and BD patients suggesting BD and UD have different neurophysiological underpinnings. Our study contributes toward the biological determination of morphometric changes, which could help to discriminate between UD and BD.
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影响因子：
11
作者：
Andreou C;Borgwardt S
通讯作者：
Borgwardt S
通过大脑结构形态计量学区分双极性和主要抑郁症：一项试点研究。
影响因子：
4.4
作者：
Fung G;Deng Y;Zhao Q;Li Z;Qu M;Li K;Zeng YW;Jin Z;Ma YT;Yu X;Wang ZR;Shum DH;Chan RC
通讯作者：
Chan RC
影响因子：
6.6
作者：
Han, Kyu-Man;Choi, Sunyoung;Ham, Byung-Joo
通讯作者：
Ham, Byung-Joo
影响因子：
5.4
作者：
Cerullo MA;Eliassen JC;Smith CT;Fleck DE;Nelson EB;Strawn JR;Lamy M;DelBello MP;Adler CM;Strakowski SM
通讯作者：
Strakowski SM
影响因子：
6.6
作者：
Donix, Markus;Haussmann, Robert;Buthut, Maria
通讯作者：
Buthut, Maria