DTI correlates of distinct cognitive impairments in Parkinson's disease.
DTI correlates of distinct cognitive impairments in Parkinson's disease.
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DTI在帕金森氏病中明显的认知障碍的相关性。
DOI：
10.1002/hbm.22256
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发表时间：
2014-04
影响因子：
4.8
通讯作者：
Pouratian, Nader
中科院分区：
文献类型：
--
作者：
Zheng, Zhong;Shemmassian, Shirag;Wijekoon, Christopher;Kim, Won;Bookheimer, Susan Y.;Pouratian, Nader
帕金森病（PD）的认知症状谱可以跨越各个领域，包括执行功能，语言，注意力，记忆和视觉空间技能。这些症状可能归因于与潜在神经退行性过程相关的投射纤维的降解。本研究的主要目的是使用扩散张量成像（DTI）在PD患者的这些认知领域中找到微结构损伤的相关性。回顾性分析16例PD患者的神经心理学综合评估和DTI数据。计算40个感兴趣区域（ROI）的各向异性分数（FA）和平均扩散率（MD）值，并对每个领域的神经认知评分进行回归。在大多数额叶白色物质束，特别是内囊前肢和胼胝体前部，执行功能与FA直接相关，与MD负相关。同样，语言和注意力表现与额区的DTI参数相关，但注意力领域还招募了遍布大脑的区域，其中扣带回（扣带）的相关性最显著。最后，记忆障碍主要涉及穹窿内的MD改变。视觉空间技能和DTI测量之间没有显着的相关性。尽管有一些重叠，但白色物质扩散的独特模式是PD患者不同认知领域损伤的基础。DTI结合神经认知测试可能是识别PD认知障碍的有价值的生物标志物。
The spectrum of cognitive symptoms in Parkinson’s disease (PD) can span various domains, including executive function, language, attention, memory and visuospatial skills. These symptoms may be attributable to the degradation of projection fibers associated with the underlying neurodegenerative process. The primary purpose of this study is to find microstructural correlates of impairments across these cognitive domains in PD using diffusion tensor imaging (DTI). Sixteen PD patients with comprehensive neuropsychological evaluation and DTI data were retrospectively studied. Fractional anisotropy (FA) and mean diffusivity (MD) values were calculated for 40 regions of interest (ROIs) and were regressed against neurocognitive scores in each domain. Executive function directly correlated with FA and inversely correlated with MD in mostly frontal white matter tracts, especially the anterior limb of the internal capsule and genu of the corpus callosum. Likewise, language and attentional performance demonstrated correlations with DTI parameters in the frontal regions, but the attention domain additionally recruited regions widespread throughout the brain, with the most significant correlation identified in cingulate gyrus (cingulum). Lastly, memory impairment mainly involved MD alterations within the fornix. No significant correlations were found between visuospatial skills and DTI measures. Despite some overlap, unique patterns of white matter diffusivity underlie impairments in distinct cognitive domains in patients with PD. DTI combined with neurocognitive tests may be a valuable biomarker for identifying cognitive impairments in PD.
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影响因子：
11.2
作者：
Goris, An;Williams-Gray, Caroline H.;Sawcer, Stephen J.
通讯作者：
Sawcer, Stephen J.
DOI：
10.1016/j.jalz.2011.05.2416
发表时间：
2012
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Mielke MM;Okonkwo OC;Oishi K;Mori S;Tighe S;Miller MI;Ceritoglu C;Brown T;Albert M;Lyketsos CG
通讯作者：
Lyketsos CG
影响因子：
14.5
作者：
LEES, AJ;SMITH, E
通讯作者：
SMITH, E
影响因子：
2.4
作者：
McKinlay, A.;Grace, R. C.;Roger, D.
通讯作者：
Roger, D.
影响因子：
3.5
作者：
Kendi, A. T. Karagulle;Lehericy, S.;Tuite, P.
通讯作者：
Tuite, P.