Vitamin C in plasma is inversely related to blood pressure and change in blood pressure during the previous year in young Black and White women.
Vitamin C in plasma is inversely related to blood pressure and change in blood pressure during the previous year in young Black and White women.
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DOI：
10.1186/1475-2891-7-35
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发表时间：
2008-12-17
影响因子：
5.4
通讯作者：
Crawford PB
中科院分区：
文献类型：
--
作者：
Block G;Jensen CD;Norkus EP;Hudes M;Crawford PB
高血压的患病率及其对心血管疾病风险的贡献使得确定可能有助于预防这种疾病的因素势在必行。大量的生物学和生物化学数据表明，血浆抗坏血酸可能是这样一个因素。在这项研究中，我们研究了血浆抗坏血酸浓度和血压（BP）之间的关系，在10-成年妇女。参与者为242名黑人和白色女性，年龄18-21岁，来自加利福尼亚州里士满，国家心肺血液研究所生长和健康研究队列。我们研究了血浆抗坏血酸与第10年随访时血压的关系，以及与前一年血压变化的关系。在横断面分析中，校正种族、体重指数、教育和脂肪和钠的饮食摄入后，第10年的血浆抗坏血酸与收缩压和舒张压呈负相关。血浆抗坏血酸分布最高的四分之一的人比分布最低的四分之一的人收缩压低4.66 mmHg（95% CI 1.10至8.22 mmHg，p = 0.005），舒张压低6.04 mmHg（95% CI 2.70至9.38 mmHg，p = 0.0002）。在血压变化的分析中，血浆抗坏血酸也与前一年收缩压和舒张压的变化呈负相关。从第9年到第10年，血浆抗坏血酸水平最低的四分位数人群的舒张压增加了5.97 mmHg（95% CI 3.82至8.13 mmHg），而血浆维生素C水平最高的四分位数人群的舒张压仅增加了0.23 mmHg（95% CI -1.90至+2.36 mmHg）（线性趋势检验：p < 0.0001）。收缩压的变化也有类似的影响，p = 0.005。血浆抗坏血酸被发现与血压和血压的变化在前一年呈负相关。研究结果表明，维生素C可能会影响健康年轻人的血压。由于青年期较低的血压可能导致老年人血压降低和年龄相关性血管事件发生率降低，因此有必要进一步研究维生素C对年轻人血压调节的治疗效果。
The prevalence of hypertension and its contribution to cardiovascular disease risk makes it imperative to identify factors that may help prevent this disorder. Extensive biological and biochemical data suggest that plasma ascorbic acid may be such a factor. In this study we examined the association between plasma ascorbic acid concentration and blood pressure (BP) in young-adult women. Participants were 242 Black and White women aged 18–21 yr from the Richmond, CA, cohort of the National Heart, Lung and Blood Institute Growth and Health Study. We examined the associations of plasma ascorbic acid with BP at follow-up year 10, and with change in BP during the previous year. In cross-sectional analysis, plasma ascorbic acid at year 10 was inversely associated with systolic BP and diastolic BP after adjusting for race, body mass index, education, and dietary intake of fat and sodium. Persons in the highest one-fourth of the plasma ascorbic acid distribution had 4.66 mmHg lower systolic BP (95% CI 1.10 to 8.22 mmHg, p = 0.005) and 6.04 mmHg lower diastolic BP (95% CI 2.70 to 9.38 mmHg, p = 0.0002) than those in the lowest one-fourth of the distribution. In analysis of the change in BP, plasma ascorbic acid was also inversely associated with change in systolic BP and diastolic BP during the previous year. While diastolic blood pressure among persons in the lowest quartile of plasma ascorbic acid increased by 5.97 mmHg (95% CI 3.82 to 8.13 mmHg) from year 9 to year 10, those in the highest quartile of plasma vitamin C increased by only 0.23 mmHg (95% CI -1.90 to +2.36 mmHg) (test for linear trend: p < 0.0001). A similar effect was seen for change in systolic BP, p = 0.005. Plasma ascorbic acid was found to be inversely associated with BP and change in BP during the prior year. The findings suggest the possibility that vitamin C may influence BP in healthy young adults. Since lower BP in young adulthood may lead to lower BP and decreased incidence of age-associated vascular events in older adults, further investigation of treatment effects of vitamin C on BP regulation in young adults is warranted.
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影响因子：
168.9
作者：
Duffy, SJ;Gokce, N;Vita, JA
通讯作者：
Vita, JA
影响因子：
4.9
作者：
Fotherby, MD;Williams, JC;Ferns, GA
通讯作者：
Ferns, GA
影响因子：
4.2
作者：
Hajjar, Ihab M;George, Varghese;Kochar, Mahendr S
通讯作者：
Kochar, Mahendr S
影响因子：
8.3
作者：
Kim, MK;Sasaki, S;Tsugane, S
通讯作者：
Tsugane, S
影响因子：
4.5
作者：
CHOI, ESK;JACQUES, PF;JACOB, RA
通讯作者：
JACOB, RA