Electrocortical measures of win and loss processing are associated with mesocorticolimbic functional connectivity: A combined ERP and rs-fMRI study.
Electrocortical measures of win and loss processing are associated with mesocorticolimbic functional connectivity: A combined ERP and rs-fMRI study.
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DOI：
10.1111/psyp.14118
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发表时间：
2022-12
期刊：
影响因子：
3.7
通讯作者：
Phan, K. Luan
中科院分区：
文献类型：
--
作者：
Crane, Natania A.;Burkhouse, Katie L.;Gorka, Stephanie M.;Klumpp, Heide;Phan, K. Luan
奖赏正性(RewP)事件相关电位是一种行之有效的奖赏加工测量方法，与内化精神病态有关。RewP被认为反映了中皮质边缘系统中的奖赏反应；然而，RewP与奖赏相关脑区的功能连接如何相关尚不清楚。目前的研究在患有内在化精神病理学(IP)的成年人和健康对照组(HC)中检测了REWP(Win和Lost残留物)和静息状态fMRI(rs-fMRI)之间的关系。所有参与者(N=1102)在脑电和rS-fMRI期间完成了一项有效的金钱奖励任务。用(1)RewP-Win残余波幅与纹状体种子(尾状核、壳核、伏隔核)和(2)RewP-Lost残余波幅与前扣带回(ACC)种子进行回归分析。总体而言，REWP-WIN残留幅度较大的个体显示，纹状体区域和内侧前额叶皮质以及海马旁回之间的Rs-fMRI连接性增加，但纹状体区域和参与认知控制和感觉运动处理的区域之间的连接性降低。更大的RewP-Lost残留量与ACC与参与奖赏/损失处理和运动控制的区域之间的更高连接性有关，但ACC与参与认知控制的区域之间的连接性降低。在IP和HC中，REWP和RS-fMRI之间的关系大体一致。然而，有几种模式是IP所独有的。结果表明，REWP与奖赏和损失相关脑区的静息状态功能连通性有关，提示中皮质边缘系统的连通性可能是奖赏和损失获得维度的一个重要的个体差异因素。我们的结果首次提供了初步证据，表明REWP是对奖赏和损失的初始反应的神经生理标记物，在有和没有内在化精神病理的个体中，REWP与静息状态fMRI期间中皮质边缘系统的功能连接有关。大脑皮质边缘的连通性可能是决定个体对奖赏和损失的反应的一个重要的个体差异因素。
The reward positivity (RewP) event‐related potential is a well‐validated measure of reward processing implicated in internalizing psychopathologies. The RewP is thought to reflect reward reactivity in the mesocorticolimbic system; however, it is not clear how the RewP is related to the functional connectivity of reward‐related brain regions. The current study examined associations between the RewP (Win and Loss residuals) and resting‐state fMRI (rs‐fMRI), among adults with internalizing psychopathology (IP) and healthy controls (HC). All participants (N = 102) completed a validated monetary reward task during electroencephalogram and rs‐fMRI. Regression analyses were conducted with (1) RewP‐Win residual amplitude and striatal seeds (caudate, putamen, nucleus accumbens) and (2) RewP‐Loss residual amplitude and anterior cingulate cortex (ACC) seeds. Overall, individuals with greater RewP‐Win residual amplitude demonstrated increased rs‐fMRI connectivity between striatal regions and the medial prefrontal cortex, as well as the parahippocampal gyrus, but decreased connectivity between striatal regions and regions involved in cognitive control and sensorimotor processing. Greater RewP‐Loss residual was related to greater connectivity between the ACC and regions involved in reward/loss processing and motor control, but decreased connectivity between the ACC and regions involved in cognitive control. Relationships between the RewP and rs‐fMRI were generally consistent across IP and HC. However, a few patterns were unique to IP. Results indicate the RewP is associated with resting‐state functional connectivity of reward‐ and loss‐related brain regions, suggesting connectivity of the mesocorticolimbic system may be an important individual difference factor in dimensions of attainment of reward and loss. Our results provide the first preliminary evidence that the RewP, a neurophysiological marker of initial response to reward and loss, is associated with functional connectivity of the mesocorticolimbic system during resting‐state fMRI among individuals with and without internalizing psychopathologies. Mesocorticolimbic connectivity may be an important individual difference factor in determining how individuals respond to the attainment of reward and loss.
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