Lateralized deficits in arousal processing after insula lesions: Behavioral and autonomic evidence
Lateralized deficits in arousal processing after insula lesions: Behavioral and autonomic evidence
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岛叶损伤后唤醒处理的偏侧化缺陷：行为和自主神经证据
DOI：
10.1101/2021.03.24.436828
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发表时间：
2021
期刊：
影响因子：
3.6
通讯作者：
Straube T.
中科院分区：
文献类型：
--
作者：
Holtmann O;Franz M;Moenig C;Tenberge J.-G;Schloßmacher I;Ivanova I;Preul C;Schwindt W;Melzer N;Miltner W. H. R;Straube T.
大量证据表明，岛叶皮层在情绪处理中起着关键作用。然而，复杂的结构和偏侧化的情绪缺陷后，岛叶损伤还不清楚。在这里，我们调查了情绪评级的效价和唤醒和皮肤电导反应（SCR）的一系列分级的情绪激动的场景中，左（n= 10）或右（n= 9）岛叶损伤的患者和健康对照组（n= 18）。我们发现，与左侧病变患者和健康对照组相比，右侧病变患者的总体SCR、唤醒等级和肢体效价评分显著降低。右岛叶损害程度与觉醒程度、SCR和肢体衰减程度显著相关。对主观唤醒等级和主观唤醒等级之间的相关性进行了额外的分析。SCR和规范性唤醒评级显示，两个病变组有评估和生理困难，发现刺激唤醒的变化。虽然没有出现组间差异的总体评级的效价，主观和规范的效价评级之间的相关性分析显示显着降低的准确性在右病变患者，左病变患者和健康对照组相比。我们的研究结果支持这一假设，即左，右岛subserve不同的功能，在情绪处理，可能是由于不对称的自主信息表示在左，右人类前脑。右丘脑可能是交感神经兴奋和认知情感加工的重要节点。
A large body of evidence ascribes a pivotal role in emotion processing to the insular cortex. However, the complex structure and lateralization of emotional deficits following insular damage are not understood. Here, we investigated emotional ratings of valence and arousal and skin conductance responses (SCR) to a graded series of emotionally arousing scenes in patients with left (n= 10) or right (n= 9) insular damage and in healthy controls (n= 18). We found a significant reduction in overall SCRs, arousal ratings and valence extremity scores in right-lesioned patients, as compared to left-lesioned patients and healthy controls. The degree of right insular damage was significantly correlated with the degree of arousal, SCR and extremity attenuation. Additional analyses of correlations between subjective arousal ratings resp. SCR and normative arousal ratings revealed that both lesion groups had evaluative and physiological difficulties to discover changes in stimulus arousal. Although no group differences emerged on overall ratings of valence, analysis of correlations between subjective and normative valence ratings displayed markedly reduced accuracy in right-lesioned patients, as compared to left-lesioned patients and healthy controls. Our findings support the hypothesis that the left and right insulae subserve different functions in emotion processing, potentially due to asymmetrical representations of autonomic information in the left and right human forebrain. The right insula may serve as integral node for sympathetic arousal and cognitive-affective processing.
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