Discrete place fields of hippocampal formation interneurons.

Discrete place fields of hippocampal formation interneurons.
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海马结构中间神经元的离散位置区域。

DOI:
10.1152/jn.01200.2006
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发表时间:
2007
影响因子:
2.5
通讯作者:
D. Nitz
D. Nitz
中科院分区:
医学3区
文献类型:
--
作者:
W. Wilent;D. Nitz;D. Nitz

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海马兴奋性主细胞(也称为“位置细胞”)的棘波放电具有高度的位置特异性,但局部抑制性中间神经元的放电被认为表现出相对较低的空间特异性。而在其他大脑区域,如感觉新皮层,中间神经元的活动往往是精致的刺激选择性,并直接决定相邻的兴奋性神经元的反应,海马中间神经元的活动通常缺乏必要的特异性,需要塑造主细胞场的定义结构。在这里,我们表明,海马结构中间神经元有“上”字段(突然增加的活动)和“关”字段(突然减少的活动),与相同的位置特定的信息内容,空间分辨率,并依赖于上下文作为“地方字段”的CA 1主细胞。这表明中间神经元具有明确的位置场,因此对于理解海马体如何表示空间信息具有重要意义。
The spike discharge of hippocampal excitatory principal cells, also called "place cells," is highly location specific, but the discharge of local inhibitory interneurons is thought to display relatively low spatial specificity. Whereas in other brain regions, such as sensory neocortex, the activity of interneurons is often exquisitely stimulus selective and directly determines the responses of neighboring excitatory neurons, the activity of hippocampal interneurons typically lacks the requisite specificity needed to shape the defined structure of principal cell fields. Here we show that hippocampal formation interneurons have "on" fields (abrupt increases in activity) and "off" fields (abrupt decreases in activity) that are associated with the same location-specific informational content, spatial resolution, and dependency on context as the "place fields" of CA1 principal cells. This establishes that interneurons have well-defined place fields, thus having important implications for understanding how the hippocampus represents spatial information.
DOI: 10.1126/science.8351520
发表时间: 1993-08-20
期刊: SCIENCE
影响因子: 56.9
作者:
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DOI: --
发表时间: 1999
期刊: Learning & memory (Cold Spring Harbor, N.Y.)
影响因子: --
作者:
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期刊: SCIENCE
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