Localized measures of callosal atrophy are associated with late-life hypertension: AGES-Reykjavik Study.
Localized measures of callosal atrophy are associated with late-life hypertension: AGES-Reykjavik Study.
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胼胝体萎缩的局部测量与晚年高血压相关：AGES-雷克雅未克研究。
DOI：
10.1016/j.neuroimage.2008.07.007
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发表时间：
2008-11-15
期刊：
影响因子：
5.7
通讯作者：
Carmichael, Owen T.
中科院分区：
文献类型：
--
作者：
Harris, Peter;Alcantara, Dan A.;Amenta, Nina;Lopez, Oscar L.;Eiriksdottir, Guony;Sigurosson, Sigurour;Gudnason, Villmundur;Madsen, Sarah;Thompson, Paul M.;Launer, Lenore J.;Carmichael, Owen T.
高血压在老年人中非常普遍，可能与认知能力下降有关，但高血压可能影响大脑结构，从而调节晚年认知表现的时间进程的机制尚不清楚。因此，我们使用一种新的计算方法-局部成分分析，在大规模的老龄化流行病学研究-年龄、基因/环境易感性-雷克雅未克研究(AGES-Reykjavik)中，测量了年龄、基因/环境易感性-雷克雅未克研究(AGES-Reykjavik)中年龄、基因/环境易感性-雷克雅未克研究(AGES-Reykjavik)中年龄、基因/环境易感性-雷克雅未克研究(AGES-Reykjavik)中28名年龄在75-79岁的右利手女性被试的空间-局部化模式。在控制了年龄的线性统计模型中，位于后中体和压部的局限性的骨痂萎缩与收缩压显著相关，而血压和前CC萎缩指标之间的相关性在统计学上并不显著。此外，全球CC萎缩的总体指标与血压没有显著相关性。后侧CC可能易受高血压相关性萎缩的影响，可能是由于其相对稀疏的血管形成。
Hypertension is highly prevalent in elderly individuals and may be associated with cognitive decline, but the mechanisms by which hypertension may impact brain structure, and thereby modulate the time course of late-life cognitive performance, are not well understood. Therefore we used Localized Components Analysis, a novel computational method, to measure spatially-localized patterns of corpus callosum (CC) atrophy in 28 right-handed female subjects aged 75-79 years in the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik), a large-scale epidemiological study of aging. Localized callosal atrophy in the posterior midbody and splenium was significantly associated with systolic blood pressure in linear statistical models that controlled for age, while associations between blood pressure and anterior CC atrophy measures were not statistically significant. Additionally, overall measures of global CC atrophy were not significantly associated with blood pressure. The posterior CC may be differentially vulnerable to hypertension-associated atrophy, possibly due to its relatively tenuous vascularization.
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影响因子：
4.4
作者：
DeCarli, C
通讯作者：
DeCarli, C
影响因子：
14.5
作者：
Funnell, MG;Corballis, PM;Gazzaniga, MS
通讯作者：
Gazzaniga, MS
DOI：
10.1111/j.1532-5415.1996.tb03736.x
发表时间：
1996-07-01
影响因子：
6.3
作者：
Janowsky, JS;Kaye, JA;Carper, RA
通讯作者：
Carper, RA
影响因子：
8.3
作者：
Kilander, L;Nyman, H;Lithell, H
通讯作者：
Lithell, H
影响因子：
8.3
作者：
Korf, ESC;White, LR;Launer, LJ
通讯作者：
Launer, LJ