Oxytocin administration enhances controlled social cognition in patients with schizophrenia.
Oxytocin administration enhances controlled social cognition in patients with schizophrenia.
复制标题
DOI：
10.1016/j.psyneuen.2014.04.024
复制
发表时间：
2014-09
影响因子：
3.7
通讯作者：
Vinogradov, S.
中科院分区：
文献类型：
--
作者：
Woolley, J. D.;Chuang, B.;Lam, O.;Lai, W.;O'Donovan, A.;Rankin, K. P.;Mathalon, D. H.;Vinogradov, S.
精神分裂症患者在自动和受控的社会认知方面存在功能上的显着缺陷，但目前没有可用的药物治疗可以减少这些缺陷。神经肽催产素具有多种亲社会的影响时，给药鼻内在人类和有越来越多的兴趣在精神分裂症的治疗潜力。在一项随机、双盲、安慰剂对照、交叉研究中，我们给29名男性精神分裂症患者和31名年龄匹配的健康对照者鼻内注射40 IU催产素和生理盐水安慰剂。社会认知采用社会推理意识测验（TASIT）和眼内阅读测验（RMET）进行评估。我们研究了催产素对自动社会认知的影响（快速解释和理解来自声音，面部和身体的情感线索的能力）;控制的社会认知（通过较长时间的复杂思考来理解间接表达的情感、思想和意图的能力）;和对照任务（理解真实对话和执行一般任务程序的能力）在有和没有精神分裂症的个人使用混合因子方差分析模型。与健康对照组相比，精神分裂症患者在自动和控制性社会认知方面表现出显著的损害，催产素的施用显著改善了他们的控制性社会认知，但不是自动性社会认知，F（1，58）= 8.75; p = 0.004。相反，催产素给药对健康参与者的社会认知影响有限。患者和对照组表现同样良好，催产素给药对控制任务没有影响。精神分裂症患者完整的社会认知能力与更好的功能结局相关。我们的数据突出了催产素对社会认知的某些但不是所有方面的潜在复杂影响，并支持探索鼻内催产素作为一种潜在的辅助治疗，以改善精神分裂症的控制社会认知。爱思唯尔有限公司出版
Individuals with schizophrenia have functionally significant deficits in automatic and controlled social cognition, but no currently available pharmacologic treatments reduce these deficits. The neuropeptide oxytocin has multiple prosocial effects when administered intranasally in humans and there is growing interest in its therapeutic potential in schizophrenia. We administered 40 IU of oxytocin and saline placebo intranasally to 29 male subjects with schizophrenia and 31 age-matched, healthy controls in a randomized, double-blind, placebo-controlled, cross-over study. Social cognition was assessed with The Awareness of Social Inference Test (TASIT) and the Reading the Mind in the Eyes Test (RMET). We examined the effects of oxytocin administration on automatic social cognition (the ability to rapidly interpret and understand emotional cues from the voice, face, and body); controlled social cognition (the ability to comprehend indirectly expressed emotions, thoughts, and intentions through complex deliberations over longer time periods); and a control task (the ability to comprehend truthful dialog and perform general task procedures) in individuals with and without schizophrenia using mixed factorial analysis of variance models. Patients with schizophrenia showed significant impairments in automatic and controlled social cognition compared to healthy controls, and administration of oxytocin significantly improved their controlled, but not automatic, social cognition, F(1, 58) = 8.75; p = 0.004. Conversely, oxytocin administration had limited effects on social cognition in healthy participants. Patients and controls performed equally well and there were no effects of oxytocin administration on the control task. Intact social cognitive abilities are associated with better functional outcomes in individuals with schizophrenia. Our data highlight the potentially complex effects of oxytocin on some but not all aspects of social cognition, and support the exploration of intranasal oxytocin as a potential adjunct treatment to improve controlled social cognition in schizophrenia. Published by Elsevier Ltd.
登录
查看更多内容
影响因子：
10.6
作者：
Guastella, Adam J.;Einfeld, Stewart L.;Hickie, Ian B.
通讯作者：
Hickie, Ian B.
影响因子：
1.7
作者：
Harrington, Leigh;Siegert, Richard J;McClure, John
通讯作者：
McClure, John
影响因子：
4.3
作者：
Fischer-Shofty M;Shamay-Tsoory SG;Levkovitz Y
通讯作者：
Levkovitz Y
影响因子：
10.6
作者：
Andreasen, Nancy C.;Pressler, Marcus;Nopoulos, Peg;Miller, Del;Ho, Beng-Choon
通讯作者：
Ho, Beng-Choon
影响因子：
4.5
作者：
Bora, Emre;Yucel, Murat;Pantelis, Christos
通讯作者：
Pantelis, Christos