Discharge Identity of Medullary Inspiratory Neurons is Altered during Repetitive Fictive Cough.
Discharge Identity of Medullary Inspiratory Neurons is Altered during Repetitive Fictive Cough.
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DOI：
10.3389/fphys.2012.00223
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发表时间：
2012
影响因子：
4
通讯作者：
Bolser DC
中科院分区：
文献类型：
--
作者：
Segers LS;Nuding SC;Vovk A;Pitts T;Baekey DM;O'Connor R;Morris KF;Lindsey BG;Shannon R;Bolser DC
本研究观察了猫重复性假咳嗽时腹侧呼吸柱尾侧（cVRC）和吻侧（rVRC）吸气递减（I-Dec）和吸气增强（I-Aug）神经元放电特性的稳定性。通过机械刺激胸内气管引起虚构性咳嗽。大约43%（10/23）的I-Dec神经元在第一个咳嗽周期（C1）转变为增强放电模式。到第二个咳嗽周期（C2），其中一半恢复到递减模式。大约94%（16/17）的I-Aug神经元在多次咳嗽反应发作的C1期间保留了增强模式。膈爆发振幅和吸气持续时间增加，在C1，但减少与随后的咳嗽在一系列的重复咳嗽。作为评估模型驱动假设的一个步骤，即VRC I-Dec神经元通过抑制抑制运动前吸气神经元的VRC紧张性呼气神经元来促进咳嗽期间吸气驱动的增强，交叉相关分析被用于评估紧张性呼气细胞与同时记录的吸气神经元的关系。我们的研究结果表明，在重复咳嗽期间，呼吸模式发生器的吸气相关子网络的重新配置会逐周期发生。
This study investigated the stability of the discharge identity of inspiratory decrementing (I-Dec) and augmenting (I-Aug) neurons in the caudal (cVRC) and rostral (rVRC) ventral respiratory column during repetitive fictive cough in the cat. Inspiratory neurons in the cVRC (n = 23) and rVRC (n = 17) were recorded with microelectrodes. Fictive cough was elicited by mechanical stimulation of the intrathoracic trachea. Approximately 43% (10 of 23) of I-Dec neurons shifted to an augmenting discharge pattern during the first cough cycle (C1). By the second cough cycle (C2), half of these returned to a decrementing pattern. Approximately 94% (16 of 17) of I-Aug neurons retained an augmenting pattern during C1 of a multi-cough response episode. Phrenic burst amplitude and inspiratory duration increased during C1, but decreased with each subsequent cough in a series of repetitive coughs. As a step in evaluating the model-driven hypothesis that VRC I-Dec neurons contribute to the augmentation of inspiratory drive during cough via inhibition of VRC tonic expiratory neurons that inhibit premotor inspiratory neurons, cross-correlation analysis was used to assess relationships of tonic expiratory cells with simultaneously recorded inspiratory neurons. Our results suggest that reconfiguration of inspiratory-related sub-networks of the respiratory pattern generator occurs on a cycle-by-cycle basis during repetitive coughing.
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影响因子：
3.3
作者：
Morris, K. F.;Nuding, S. C.;Dick, T. E.
通讯作者：
Dick, T. E.
影响因子：
2.9
作者：
BOLSER, DC;DEGENNARO, FC
通讯作者：
DEGENNARO, FC
DOI：
10.1152/ajpregu.1998.274.4.r1015
发表时间：
1998-04-01
影响因子：
2.8
作者：
Bongianni, F;Mutolo, D;Pantaleo, T
通讯作者：
Pantaleo, T
影响因子：
3.3
作者：
BOLSER, DC
通讯作者：
BOLSER, DC
影响因子：
25
作者：
Lieske, SP;Thoby-Brisson, M;Ramirez, JM
通讯作者：
Ramirez, JM