Maternal smoking during pregnancy and daughters' risk of gestational diabetes and obesity.
Maternal smoking during pregnancy and daughters' risk of gestational diabetes and obesity.
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DOI：
10.1007/s00125-013-2936-7
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发表时间：
2013-08
期刊：
影响因子：
8.2
通讯作者：
Rylander, L.
中科院分区：
文献类型：
--
作者：
Mattsson, K.;Kallen, K.;Longnecker, M. P.;Rignell-Hydbom, A.;Rylander, L.
关键词：
研究在子宫内接触烟草烟雾的妇女患妊娠糖尿病的风险。次要目的是评估肥胖和非妊娠糖尿病的风险。从瑞典医疗出生登记册中检索了1982年（首次登记的吸烟数据）或之后出生并至少生过一个孩子的妇女的数据；其中包括80189例妊娠。评估了子宫内吸烟暴露（三种类型：不吸烟者、1-9支/天[中等暴露]和10 - 9支/天[严重暴露]）与随后的妊娠糖尿病（n=291）、非妊娠糖尿病（n=280）和肥胖（n=7300）之间的关系。在中度暴露（aOR 1.62, 95%可信区间（CI）： 1.24-2.13）和重度暴露（aOR 1.52, CI: 1.12-2.06）的妇女中，妊娠期糖尿病的调整优势比（aOR）增加。相应的肥胖优势比分别为（aOR 1.36, CI 1.28-1.44）和（aOR 1.58, CI 1.48-1.68）。重度吸烟者的后代患非妊娠期糖尿病的优势比降低（aOR=0.66, CI: 0.45-0.96）。在胎儿时期接触吸烟的妇女患妊娠期糖尿病和肥胖症的风险更高。
To study the risk of developing gestational diabetes in women who were exposed to tobacco smoke in utero. Secondary aims were to assess the risk of obesity and non-gestational diabetes. Data were retrieved from the Medical Birth Register of Sweden for women who were born in 1982 (smoking data first registered) or later and who had given birth to at least one child; 80 189 pregnancies were included. The associations between in utero smoking exposure (three categories: non-smokers, 1–9 cigarettes/day [moderately exposed], and >9 cigarettes/day [heavily exposed]) and subsequent gestational diabetes (n=291), non-gestational diabetes (n=280) and obesity (n=7300) were assessed. The adjusted odds ratios (aOR) of gestational diabetes were increased among women who were moderately (aOR 1.62, 95% confidence interval (CI): 1.24–2.13) and heavily exposed (aOR 1.52, CI: 1.12–2.06). The corresponding odds ratios of obesity were (aOR 1.36, CI: 1.28–1.44) and (aOR 1.58, CI 1.48–1.68), respectively. A reduced odds ratio for non-gestational diabetes was seen in the offspring of heavy smokers (aOR=0.66, CI: 0.45–0.96). Women exposed to smoking during fetal life were at higher risk of developing gestational diabetes and obesity.
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影响因子：
4.1
作者：
Somm, Emmanuel;Schwitzgebel, Valerie M.;Hueppi, Petra S.
通讯作者：
Hueppi, Petra S.
影响因子：
5.3
作者：
Power, C.;Atherton, K.;Thomas, C.
通讯作者：
Thomas, C.
DOI：
10.1093/toxsci/kfq103
发表时间：
2010-08
期刊：
Toxicological sciences : an official journal of the Society of Toxicology
影响因子：
--
作者：
Bruin JE;Gerstein HC;Holloway AC
通讯作者：
Holloway AC
影响因子：
4.2
作者：
Plagemann, A;Harder, T;Dörner, G
通讯作者：
Dörner, G
影响因子：
7.7
作者：
Iliadou, Anastasia Nyman;Koupil, Ilona;Cnattingius, Sven
通讯作者：
Cnattingius, Sven