Modulation of spontaneous breathing via limbic/paralimbic-bulbar circuitry: an event-related fMRI study.
Modulation of spontaneous breathing via limbic/paralimbic-bulbar circuitry: an event-related fMRI study.
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DOI：
10.1016/j.neuroimage.2009.05.025
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发表时间：
2009-09
期刊：
影响因子：
5.7
通讯作者：
Lazar, Sara W.
中科院分区：
文献类型：
--
作者：
Evans, Karleyton C.;Dougherty, Darin D.;Schmid, Annette M.;Scannell, Elizabeth;McCallister, Adrienne;Benson, Herbert;Dusek, Jeffery A.;Lazar, Sara W.
脑干中的起搏神经元为代谢稳态和生存提供呼吸的自动控制，这是公认的。在清醒自主呼吸期间，认知和情感需求可以调节固有的脑干呼吸节律。然而，神经回路介导这种调制是未知的。脑桥上对呼吸控制影响的研究涉及边缘/延髓-延髓回路，但这些研究仅限于侵入性外科电生理方法或大量呼吸激发期间的神经成像。在这里，我们探讨了在休息时以及在一个具有挑战性的认知任务（持续的随机数生成）的自主呼吸过程中的呼吸相关的神经活动的边缘/延髓电路。在每种情况下，对14名健康受试者进行功能性磁共振成像（fMRI）并同时进行生理监测（心率、呼吸率、潮气量、潮气末二氧化碳）。认知任务产生了预期的呼吸频率增加，而潮气末二氧化碳和心率在不同条件下没有显着差异。在SPM 5中，呼吸周期作为逐呼吸、事件相关、逐体素、随机效应图像分析的输入函数。主效应分析（认知任务+休息）证明了与延髓、脑桥、中脑、杏仁核、前扣带和前岛叶皮质内自主呼吸相关的协调神经活动的第一个证据。条件间配对t检验（认知任务>休息）表明，该网络内的调制定位于背侧前扣带回和脑桥中缝大核。我们建议，确定边缘/延髓电路在自主呼吸的认知和情绪调节中起着重要的作用。
It is well established that pacemaker neurons in the brainstem provide automatic control of breathing for metabolic homeostasis and survival. During waking spontaneous breathing, cognitive and emotional demands can modulate the intrinsic brainstem respiratory rhythm. However the neural circuitry mediating this modulation is unknown. Studies of supra-pontine influences on the control of breathing have implicated limbic/paralimbic-bulbar circuitry, but these studies have been limited to either invasive surgical electrophysiological methods or neuroimaging during substantial respiratory provocation. Here we probed the limbic/paralimbic-bulbar circuitry for respiratory related neural activity during unlabored spontaneous breathing at rest as well as during a challenging cognitive task (sustained random number generation). Functional magnetic resonance imaging (fMRI) with simultaneous physiological monitoring (heart rate, respiratory rate, tidal volume, end-tidal CO2) was acquired in 14 healthy subjects during each condition. The cognitive task produced expected increases in breathing rate, while end-tidal CO2 and heart rate did not significantly differ between conditions. The respiratory cycle served as the input function for breath-by-breath, event-related, voxel-wise, random-effects image analyses in SPM5. Main effects analyses (cognitive task + rest) demonstrated the first evidence of coordinated neural activity associated with spontaneous breathing within the medulla, pons, midbrain, amygdala, anterior cingulate and anterior insular cortices. Between-condition paired t-tests (cognitive task > rest) demonstrated modulation within this network localized to the dorsal anterior cingulate and pontine raphe magnus nucleus. We propose that the identified limbic/paralimbic-bulbar circuitry plays a significant role in cognitive and emotional modulation of spontaneous breathing.
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DOI：
10.1073/pnas.98.4.2029
发表时间：
2001-02-13
影响因子：
11.1
作者：
Brannan, S;Liotti, M;Fox, PT
通讯作者：
Fox, PT
影响因子：
2.6
作者：
Boiten, FA
通讯作者：
Boiten, FA
影响因子：
3.3
作者：
FINK, BR
通讯作者：
FINK, BR
DOI：
10.1073/pnas.96.5.2532
发表时间：
1999-03-02
影响因子：
11.1
作者：
Denton, D;Shade, R;Fox, P
通讯作者：
Fox, P
影响因子：
2.1
作者：
Aleksandrov, VG;Aleksandrova, NP;Bagaev, VA
通讯作者：
Bagaev, VA