Host-Microbiome Interaction in Lung Cancer.
Host-Microbiome Interaction in Lung Cancer.
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DOI：
10.3389/fimmu.2021.679829
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发表时间：
2021
影响因子：
7.3
通讯作者：
Jin C
中科院分区：
文献类型：
--
作者：
Dong Q;Chen ES;Zhao C;Jin C
共生微生物群已成为肿瘤发生和癌症治疗反应的重要生物标志物和调节剂。然而，我们目前对癌症微生物群的了解主要局限于肠道微生物群。肺作为人体表面积最大的粘膜器官之一，通过吸入和微吸入暴露于多种微生物，在生理和病理状态下都被多种细菌群落定植。重要的是，越来越多的证据表明，肺部微生物群与癌症的发展有关。对肺癌患者和小鼠模型的研究表明，肺部局部微生物组的肿瘤相关失调，进而通过塑造肿瘤微环境和调节肿瘤浸润免疫细胞的活性来影响癌症进展。这些发现不仅为肺癌的生物学机制提供了新的见解，而且为肺癌的预防和治疗提供了新的治疗靶点和策略。这篇综述的目的是讨论这个新的和令人兴奋的领域的主要发现、遗留问题和未来的方向。
Commensal microbiota has emerged as an essential biomarker and regulator of both tumorigenesis and response to cancer therapy. However, our current knowledge about microbiota in cancer has been largely limited to intestinal microbiota. As a mucosal organ harboring one of the largest surface areas in the body, the lung is exposed to a variety of microbes through inhalation and micro-aspiration, and is colonized by a diverse bacterial community in both physiological and pathological conditions. Importantly, increasing evidence has linked the lung microbiome to cancer development. Studies in lung cancer patients and mouse models have revealed tumor-associated dysregulation of the local microbiome in the lung, which in turn impacts cancer progression by shaping the tumor microenvironment and modulating the activity of tumor-infiltrating immune cells. These findings not only provide novel mechanistic insight into the biology of lung cancer but also shed light on new therapeutic targets and strategies for lung cancer prevention and treatment. The goal of this review is to discuss the key findings, remaining questions, and future directions in this new and exciting field.
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影响因子：
8.3
作者：
Dickson, Robert P.;Erb-Downward, John R.;Curtis, Jeffrey L.
通讯作者：
Curtis, Jeffrey L.
影响因子：
3.7
作者：
Cameron SJS;Lewis KE;Huws SA;Hegarty MJ;Lewis PD;Pachebat JA;Mur LAJ
通讯作者：
Mur LAJ
影响因子：
168.9
作者：
Dickson, Robert P.;Martinez, Fernando J.;Huffnagle, Gary B.
通讯作者：
Huffnagle, Gary B.
影响因子：
3.7
作者：
Erb-Downward JR;Thompson DL;Han MK;Freeman CM;McCloskey L;Schmidt LA;Young VB;Toews GB;Curtis JL;Sundaram B;Martinez FJ;Huffnagle GB
通讯作者：
Huffnagle GB
DOI：
10.1016/j.jaci.2010.10.048
发表时间：
2011-02
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Huang YJ;Nelson CE;Brodie EL;Desantis TZ;Baek MS;Liu J;Woyke T;Allgaier M;Bristow J;Wiener-Kronish JP;Sutherland ER;King TS;Icitovic N;Martin RJ;Calhoun WJ;Castro M;Denlinger LC;Dimango E;Kraft M;Peters SP;Wasserman SI;Wechsler ME;Boushey HA;Lynch SV;National Heart, Lung, and Blood Institute's Asthma Clinical Research Network
通讯作者：
National Heart, Lung, and Blood Institute's Asthma Clinical Research Network