Parkinson's disease and cancer: a systematic review and meta-analysis of over 17 million participants.
Parkinson's disease and cancer: a systematic review and meta-analysis of over 17 million participants.
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DOI：
10.1136/bmjopen-2020-046329
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发表时间：
2021-07-02
期刊：
影响因子：
2.9
通讯作者：
Gao X
中科院分区：
文献类型：
--
作者：
Zhang X;Guarin D;Mohammadzadehhonarvar N;Chen X;Gao X
通过荟萃分析系统回顾和定性评价帕金森病（PD）与癌症相关性的流行病学证据。MEDLINE通过PubMed，Web of Science和EMBASE，直到2021年3月。纳入的出版物包括（1）PD和癌症的原始流行病学研究;（2）报告的风险估计;（3）英文。排除标准包括：（1）审查/评论;（2）生物学研究;（3）病例报告/尸检研究;（4）不相关暴露/结局;（5）治疗病例;（6）无风险估计指标;（7）无置信区间/精确p值和（8）重复。数据提取遵循PRISMA和MOOSE指南。两步筛选由两名彼此不知情的作者进行。使用随机效应模型计算合并相对风险（RR）。我们纳入了评估癌症患者与非癌症患者的PD风险以及PD患者与非PD患者的癌症风险的出版物。共纳入63项研究和17 994 584名参与者。荟萃分析产生的合并RR为0.82（n=33; 95% CI 0.76至0.88; p<0.001）PD与总癌症之间的相关性为0.76（n=21; 95%CI 0.67至0.85; p<0.001），非吸烟相关癌症为0.92（n=19; 95%CI 0.84至0.99; p=0.03）。PD与黑色素瘤风险增加相关（n=29;合并RR=1.75; 95%CI 1.43 - 2.14; p<0.001），但与其他皮肤癌风险增加无关（n=17;合并RR=0.90; 95%CI 0.60 - 1.34; p=0.60）。PD和总癌症呈负相关。这种负相关在吸烟相关和非吸烟相关的癌症中都存在。PD与黑色素瘤呈正相关。这些结果为进一步研究PD与癌症之间可能的机制关联提供了证据。CRD 42020162103。
To systematically review and qualitatively evaluate epidemiological evidence on associations between Parkinson’s disease (PD) and cancer via meta-analysis. MEDLINE via PubMed, Web of Science and EMBASE, until March 2021. Included were publications that (1) were original epidemiological studies on PD and cancer; (2) reported risk estimates; (3) were in English. Exclusion criteria included: (1) review/comments; (2) biological studies; (3) case report/autopsy studies; (4) irrelevant exposure/outcome; (5) treated cases; (6) no measure of risk estimates; (7) no confidence intervals/exact p values and (8) duplicates. PRISMA and MOOSE guidelines were followed in data extraction. Two-step screening was performed by two authors blinded to each other. A random-effects model was used to calculate pooled relative risk (RR). We included publications that assessed the risk of PD in individuals with vs without cancer and the risk of cancer in individuals with vs without PD. A total of 63 studies and 17 994 584 participants were included. Meta-analysis generated a pooled RR of 0.82 (n=33; 95% CI 0.76 to 0.88; p<0.001) for association between PD and total cancer, 0.76 (n=21; 95% CI 0.67 to 0.85; p<0.001) for PD and smoking-related cancer and 0.92 (n=19; 95% CI 0.84 to 0.99; p=0.03) for non-smoking-related cancer. PD was associated with an increased risk of melanoma (n=29; pooled RR=1.75; 95% CI 1.43 to 2.14; p<0.001) but not for other skin cancers (n=17; pooled RR=0.90; 95% CI 0.60 to 1.34; p=0.60). PD and total cancer were inversely associated. This inverse association persisted for both smoking-related and non-smoking-related cancers. PD was positively associated with melanoma. These results provide evidence for further investigations for possible mechanistic associations between PD and cancer. CRD42020162103.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/j.ecl.2017.07.007
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