Interleukin-10 promoter gene polymorphisms and susceptibility to tuberculosis: a meta-analysis.
Interleukin-10 promoter gene polymorphisms and susceptibility to tuberculosis: a meta-analysis.
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Interleukin-10 启动子基因多态性与结核病易感性：荟萃分析
DOI：
10.1371/journal.pone.0127496
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
Gao X;Chen J;Tong Z;Yang G;Yao Y;Xu F;Zhou J
目的探讨白细胞介素10(IL-10)基因多态性及其单倍型是否与结核病易感性有关，这是近期Meta分析的最新进展。方法计算机检索PubMed、EMBASE、Cochrane中央对照试验(CENTERY)、万方数据库和中国国家知识基础设施(CNKI)中IL-10基因多态性与结核病的病例对照研究。使用具有95%可信区间(CI)的优势比(OR)来计算关联强度。结果本研究共纳入28项研究，包括8242名结核病患者和9666名对照。在合并样本中，-1082G/A、-819C/T和-592A/C多态与结核病无显著关联。亚组分析显示，在所有遗传模型中，-819T等位基因与亚洲人结核病风险增加相关(T与C：OR=1.1795%CI=1.05~1.29，P=0.003；TT与CC：OR=1.37，95%CI=1.09~1.72，P=0.006；CT+TT与CC：OR=1.33，95%CI=1.09~1.63，P=0.006；TTvs.CT+CC：OR=1.17，95%CI=1.02~1.35，P=0.03)，-592A/C多态在两种遗传模式下与欧洲人的结核病显著相关(Avs.C：OR=0.77，95%CI=0.60~0.98，P=0.03；AA vs.CC：OR=0.53，95%CI=0.30~0.95，P=0.03)。此外，GCC IL-10启动子单倍型与结核病风险增加相关(GCC与其他人：P=1.42，95%CI=1.02~1.97，P=0.04)。基于种族的亚组分析显示，在欧洲人中，GCC单倍型与较高的结核病风险相关，而在亚洲人和欧洲人中，Acc单倍型与较低的结核病风险相关。结论IL-10-819T/C基因多态性与亚洲人群结核病发病风险相关，IL-10-592A/C基因多态性可能是欧洲人群结核病发病的危险因素之一。此外，这些数据表明，IL-10启动子单倍型在结核病的易感性或预防发展中起着至关重要的作用。
Objective As an update to other recent meta-analyses, the purpose of this study was to explore whether interleukin-10 (IL-10) polymorphisms and their haplotypes contribute to tuberculosis (TB) susceptibility. Methods We searched for published case-control studies examining IL-10 polymorphisms and TB in PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Wanfang databases and the Chinese National Knowledge Infrastructure (CNKI). Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strengths of the associations. Results A total of 28 studies comprising 8,242 TB patients and 9,666 controls were included in the present study. There were no significant associations between the -1082G/A, -819C/T, and -592A/C polymorphisms and TB in the pooled samples. Subgroup analyses revealed that the -819T allele was associated with an increased TB risk in Asians in all genetic models (T vs. C: OR=1.17, 95% CI=1.05-1.29, P=0.003; TT vs. CC: OR=1.37, 95% CI=1.09-1.72, P=0.006; CT+TT vs. CC: OR=1.33, 95% CI=1.09-1.63, P=0.006; TT vs. CT+CC: OR=1.17, 95% CI=1.02-1.35, P=0.03) and that the -592A/C polymorphism was significantly associated with TB in Europeans under two genetic models (A vs. C: OR=0.77, 95% CI=0.60-0.98, P=0.03; AA vs. CC: OR=0.53, 95% CI=0.30-0.95, P=0.03). Furthermore, the GCC IL-10 promoter haplotype was associated with an increased risk of TB (GCC vs. others: P=1.42, 95% CI=1.02-1.97, P=0.04). Subgroup analyses based on ethnicity revealed that the GCC haplotype was associated with a higher risk of TB in Europeans, whereas the ACC haplotype was associated with a lower TB risk in both Asians and Europeans. Conclusions This meta-analysis suggests that the IL-10-819T/C polymorphism is associated with the risk of TB in Asians and that the IL-10-592A/C polymorphism may be a risk factor for TB in Europeans. Furthermore, these data indicate that IL-10 promoter haplotypes play a vital role in the susceptibility to or protection against the development of TB.
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影响因子：
3.7
作者：
Hyun MH;Lee CH;Kang MH;Park BK;Lee YH
通讯作者：
Lee YH
影响因子：
5.8
作者：
Bellamy, Richard
通讯作者：
Bellamy, Richard
影响因子：
3.4
作者：
Figueiredo, José Fernando de Castro;Rodrigues, Maria de Lourdes Veronese;Donadi, Eduardo Antonio
通讯作者：
Donadi, Eduardo Antonio
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
DOI：
10.1073/pnas.140201897
发表时间：
2000-07-05
影响因子：
11.1
作者：
Bellamy, R;Beyers, N;Hill, AVS
通讯作者：
Hill, AVS