Striatal Dopaminergic Innervation Regulates Subthalamic Beta-Oscillations and Cortical-Subcortical Coupling during Movements: Preliminary Evidence in Subjects with Parkinson's Disease.
Striatal Dopaminergic Innervation Regulates Subthalamic Beta-Oscillations and Cortical-Subcortical Coupling during Movements: Preliminary Evidence in Subjects with Parkinson's Disease.
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DOI：
10.3389/fnhum.2016.00611
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发表时间：
2016
影响因子：
2.9
通讯作者：
Isaias IU
中科院分区：
文献类型：
--
作者：
Canessa A;Pozzi NG;Arnulfo G;Brumberg J;Reich MM;Pezzoli G;Ghilardi MF;Matthies C;Steigerwald F;Volkmann J;Isaias IU
在运动的准备和执行过程中，基底神经节被激活。然而，运动过程中皮质和皮质下脑区的功能相互作用以及多巴胺能纹状体神经支配的相对贡献仍不清楚。我们记录了局部场电位（LFP）活动，从丘脑底核（ESTA）和高密度脑电图（EEG）信号在4例帕金森病（PD）关闭多巴胺能药物在多关节运动任务与他们的优势和非优势的手。在手术后4个月通过完全植入式脑深部电刺激（DBS）装置进行记录。3名患者还使用[123 I]N-ω-氟丙基-2 β-甲氧羰基-3 β-（4-碘苯基）去甲托烷（FP-CIT）进行了单光子计算机断层扫描（SPECT），以评估纹状体多巴胺能神经支配。单侧运动执行导致事件相关性去同步化（ERD），然后在运动终止事件相关性同步化（ERS）后，两个半球的大脑皮层和初级感觉运动皮层的振荡β活动出现反弹。多巴胺缺乏直接影响运动相关的β-调制，在同侧和对侧手部运动中，多巴胺耗尽最多的半球具有更大的β-抑制。皮质-皮质下，但不interhemispheric皮质下的连贯性调制的运动和纹状体多巴胺能神经支配的影响，是最强的多巴胺耗尽的半球。这些数据是一致的作用，多巴胺在屏蔽皮质下结构从过度的皮质截留和跨半球耦合，从而允许微调的运动。
Activation of the basal ganglia has been shown during the preparation and execution of movement. However, the functional interaction of cortical and subcortical brain areas during movement and the relative contribution of dopaminergic striatal innervation remains unclear. We recorded local field potential (LFP) activity from the subthalamic nucleus (STN) and high-density electroencephalography (EEG) signals in four patients with Parkinson’s disease (PD) off dopaminergic medication during a multi-joint motor task performed with their dominant and non-dominant hand. Recordings were performed by means of a fully-implantable deep brain stimulation (DBS) device at 4 months after surgery. Three patients also performed a single-photon computed tomography (SPECT) with [123I]N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (FP-CIT) to assess striatal dopaminergic innervation. Unilateral movement execution led to event-related desynchronization (ERD) followed by a rebound after movement termination event-related synchronization (ERS) of oscillatory beta activity in the STN and primary sensorimotor cortex of both hemispheres. Dopamine deficiency directly influenced movement-related beta-modulation, with greater beta-suppression in the most dopamine-depleted hemisphere for both ipsi- and contralateral hand movements. Cortical-subcortical, but not interhemispheric subcortical coherencies were modulated by movement and influenced by striatal dopaminergic innervation, being stronger in the most dopamine-depleted hemisphere. The data are consistent with a role of dopamine in shielding subcortical structures from an excessive cortical entrapment and cross-hemispheric coupling, thus allowing fine-tuning of movement.
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影响因子：
4.7
作者：
Devos, D.;Szurhaj, W.;Defebvre, L.
通讯作者：
Defebvre, L.
影响因子：
5.3
作者：
de Solages, Camille;Hill, Bruce C.;Bronte-Stewart, Helen
通讯作者：
Bronte-Stewart, Helen
DOI：
10.1080/03610927708827533
发表时间：
1977-01-01
期刊：
COMMUNICATIONS IN STATISTICS PART A-THEORY AND METHODS
影响因子：
--
作者：
HOLLAND, PW;WELSCH, RE
通讯作者：
WELSCH, RE
影响因子：
8.6
作者：
Isaias, Ioannis U.;Marotta, Giorgio;Antonini, Angelo
通讯作者：
Antonini, Angelo
影响因子：
3.3
作者：
Hohlefeld, F. U.;Huchzermeyer, C.;Nikulin, V. V.
通讯作者：
Nikulin, V. V.