Endothelial progenitor cells in acute ischemic stroke.
Endothelial progenitor cells in acute ischemic stroke.
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DOI：
10.1002/brb3.175
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发表时间：
2013-11
影响因子：
3.1
通讯作者：
Badimon, Lina
中科院分区：
文献类型：
--
作者：
Marti-Fabregas, Joan;Crespo, Javier;Delgado-Mederos, Raquel;Martinez-Ramirez, Sergi;Pena, Esther;Marin, Rebeca;Dinia, Lavinia;Jimenez-Xarrie, Elena;Fernandez-Arcos, Ana;Perez-Perez, Jesus;Querol, Luis;Suarez-Calvet, Marc;Badimon, Lina
缺血性卒中中循环内皮祖细胞（EPCs）的水平尚未得到广泛研究，报道的结果也不一致。我们的目的是研究不同时间点缺血性卒中患者EPC计数的时间过程、预后相关性和相关变量。我们前瞻性地研究了146例缺血性卒中患者，这些患者在出现症状后48小时内（基线）连续出现。我们评估了人口统计数据、经典血管危险因素、溶栓和他汀类药物治疗、卒中病因、美国国立卫生研究院卒中量表评分和结果（当Rankin量表评分0-2分时有利）。在基线、中风后第7天（n = 121）和3个月（n = 92）采集血样。流式细胞术检测EPC。我们纳入146例患者，平均年龄为70.8±12.2岁。第7天循环EPC水平高于基线和第3个月（P = 0.045）。他汀类药物预处理（优势比[OR] 3.11, P = 0.008）和卒中病因学（P = 0.032）可预测基线样本中EPC计数。在所有患者中，EPC计数与卒中严重程度或功能结局无关。然而，通过多变量分析，发现在大动脉粥样硬化和小血管疾病病因亚型中EPC计数较高的患者有更好的功能结局。急性缺血性卒中后，循环EPC计数在第7天达到峰值。他汀类药物预处理使EPC水平升高。在大动脉粥样硬化和小血管疾病亚型患者中，较高的计数与3个月时较好的预后相关。
The levels of circulating endothelial progenitor cells (EPCs) in ischemic stroke have not been studied extensively and reported results are inconsistent. We aimed to investigate the time course, the prognostic relevance, and the variables associated with EPC counts in patients with ischemic stroke at different time points. We studied prospectively 146 consecutive patients with ischemic stroke within the first 48 h from the onset of symptoms (baseline). We evaluated demographic data, classical vascular risk factors, treatment with thrombolysis and statins, stroke etiology, National Institute of Health and Stroke Scale score and outcome (favorable when Rankin scale score 0–2). Blood samples were collected at baseline, at day 7 after stroke (n = 121) and at 3 months (n = 92). The EPC were measured by flow cytometry. We included 146 patients with a mean age of 70.8 ± 12.2 years. The circulating EPC levels were higher on day 7 than at baseline or at 3 months (P = 0.045). Pretreatment with statins (odds ratio [OR] 3.11, P = 0.008) and stroke etiology (P = 0.032) were predictive of EPC counts in the baseline sample. EPC counts were not associated with stroke severity or functional outcome in all the patients. However, using multivariate analyses, a better functional outcome was found in patients with higher EPC counts in large-artery atherosclerosis and small-vessel disease etiologic subtypes. After acute ischemic stroke, circulating EPC counts peaked at day 7. Pretreatment with statins increased the levels of EPC. In patients with large-artery atherosclerosis and small-vessel disease subtypes, higher counts were related to better outcome at 3 months.
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影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
影响因子：
8.3
作者：
Ghani, U;Shuaib, A;Todd, K
通讯作者：
Todd, K
影响因子：
11.2
作者：
Ay, H;Furie, KL;Koroshetz, WJ
通讯作者：
Koroshetz, WJ
影响因子：
37.8
作者：
Shintani, S;Murohara, T;Imaizumi, T
通讯作者：
Imaizumi, T
影响因子：
8.3
作者：
Jickling, Glen;Salam, Abdul;Camicioli, Richard
通讯作者：
Camicioli, Richard