The Molecular Industrial Revolution: Automated Synthesis of Small Molecules.
The Molecular Industrial Revolution: Automated Synthesis of Small Molecules.
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DOI：
10.1002/anie.201710482
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发表时间：
2018-04-09
期刊：
影响因子：
--
通讯作者：
Burke MD
中科院分区：
文献类型：
--
作者：
Trobe M;Burke MD
十八世纪和十九世纪标志着宏观规模上从手工制造向自动化制造的彻底转变。这开启了一段无与伦比的人类创新时期，推动了工业革命。它对社会产生了变革性的影响，最终使世界许多地区的生活条件和寿命得到了显着改善。在同一时期，首次实现了有机分子的手动合成。现在，两个世纪后，我们准备进行类似的转变，从手工高度定制的特定分子靶标，到通过按下按钮对许多不同类型的分子进行日益通用和自动化的组装。定制小分子合成途径的自动化已经能够实现更安全、更可重复且易于扩展的特定靶标的生产，并且现在存在用于合成各种不同肽、寡核苷酸和寡糖的通用机器。事实证明，创建同样能够按需制造多种不同类型小分子的通用机器（类似于通过 3D 打印机在宏观尺度上实现的目标）更具挑战性。然而，通过两种互补的方法，正在朝着这一潜在的变革性目标取得重要进展：（1）通过机器实现不同目标的定制合成路线自动化，从而能够使用许多不同的反应和起始材料；（2）通用平台的自动化，使用通用的偶联化学和构建模块来制造许多不同的目标。这些令人兴奋的方向的持续进展有可能将分子创新的瓶颈从合成转移到想象，从而有助于推动分子规模上的新工业革命。
The eighteenth and nineteenth centuries marked a sweeping transition from manual to automated manufacturing on the macroscopic scale. This enabled an unmatched period of human innovation that helped drive the Industrial Revolution. The impact on society was transformative, ultimately yielding substantial improvements in living conditions and lifespan in many parts of the world. During the same time period, the first manual syntheses of organic molecules was achieved. Now, two centuries later, we are poised for an analogous transition from highly customized crafting of specific molecular targets by hand to the increasingly general and automated assembly of many different types of molecules with the push of a button. Automation of customized small molecule synthesis pathways is already enabling safer, more reproducible, and readily scalable production of specific targets, and general machines now exist for the synthesis of a wide range of different peptides, oligonucleotides, and oligosaccharides. Creating general machines that are similarly capable of making many different types of small molecules on-demand, akin to that which has been achieved on the macroscopic scale with 3D printers, has proven to be substantially more challenging. Yet important progress is being made toward this potentially transformative objective with two complementary approaches: (1) automation of customized synthesis routes to different targets via machines that enable use of many different reactions and starting materials, and (2) automation of generalized platforms that make many different targets using common coupling chemistry and building blocks. Continued progress in these exciting directions has the potential to shift the bottleneck in molecular innovation from synthesis to imagination, and thereby help drive a new industrial revolution on the molecular scale.
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DOI：
10.1002/anie.201704529
发表时间：
2017-07-17
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
--
作者：
Britton J;Jamison TF
通讯作者：
Jamison TF
影响因子：
56.9
作者：
CARUTHERS, MH
通讯作者：
CARUTHERS, MH
影响因子：
1.6
作者：
Boschi, S.;Lodi, F.;Marengo, M.
通讯作者：
Marengo, M.
影响因子：
3.6
作者：
Brun, Elodie;Bellosta, Veronique;Cossy, Janine
通讯作者：
Cossy, Janine
影响因子：
4.9
作者：
Baxendale, Ian R.;Deeley, Jon;Tranmer, Geoffrey K.
通讯作者：
Tranmer, Geoffrey K.