Neonatal adiposity increases with rising cord blood IGF-1 levels.
Neonatal adiposity increases with rising cord blood IGF-1 levels.
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DOI：
10.1111/cen.13057
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发表时间：
2016-07
影响因子：
3.2
通讯作者：
Josefson JL
中科院分区：
文献类型：
--
作者：
Kadakia R;Ma M;Josefson JL
出生时肥胖程度较高的婴儿在以后的生活中患肥胖症的风险更大。IGF-1对子宫内生长很重要，可能是肥胖的早期生命标志物，因此是以后肥胖风险的标志物。本研究的目的是确定脐带血IGF-1，新生儿人体测量学和新生儿肥胖标志物之间的关系。采用横断面研究设计，研究一个大型大学医院的多种族足月新生儿队列，这些新生儿的母亲是健康的，葡萄糖耐量正常。新生儿出生后收集脐带血，测定IGF-1，瘦素和C-肽。新生儿的身体成分之间的24和72小时的生活使用的方法的空气置换体积描记法进行了测量。脐带血IGF-1与新生儿肥胖的标志物在校正了母亲分娩时的年龄、种族、母亲孕前BMI、分娩时的胎龄和新生儿性别的模型中正相关且显著相关：出生体重（r = 0.62，P <0.001）、瘦素（r = 0.33，P = 0.018）、脂肪量（r = 0.52，P <0.001）和体脂百分比（r = 0.51，P <0.001）。脐血IGF-1与脐血C肽无相关性。脐带血IGF-1与新生儿肥胖的所有指标密切相关，表明IGF-1可能是子宫内新生儿脂肪蓄积的重要因素。
Infants with higher adiposity at birth may be at greater risk of developing obesity later in life. IGF-1 is important for intrauterine growth and may be a useful early life marker of adiposity, and thus later obesity risk. The aim of this study was to determine the relationship between cord blood IGF-1, neonatal anthropometrics and markers of neonatal adiposity. A cross-sectional study design was utilized to study a multiethnic cohort of full-term neonates born to healthy mothers with normal glucose tolerance at a large university hospital. Neonatal cord blood was collected after birth and assayed for IGF-1, leptin and C-peptide. Neonatal body composition was measured between 24 and 72 h of life using the method of air displacement plethysmography. Cord blood IGF-1 was positively and significantly associated with markers of neonatal adiposity in models adjusted for maternal age at delivery, race, maternal prepregnancy BMI, gestational age at delivery and neonatal sex: birthweight (r = 0·62, P < 0·001), leptin (r = 0·33, P = 0·018), fat mass (r = 0·52, P < 0·001) and percent body fat (r = 0·51, P < 0·001). Cord blood IGF-1 was not associated with cord blood C-peptide. Cord blood IGF-1 is strongly associated with all measures of neonatal adiposity suggesting that IGF-1 may be an important contributor to in utero neonatal fat accumulation.
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影响因子：
10.5
作者：
POWELLBRAXTON, L;HOLLINGSHEAD, P;STEWART, TA
通讯作者：
STEWART, TA
影响因子：
8
作者：
Hassink, SG;deLancey, E;Funanage, VL
通讯作者：
Funanage, VL
影响因子：
5.8
作者：
Harigaya, A;Nagashima, K;Morikawa, A
通讯作者：
Morikawa, A
DOI：
10.1016/s1071-5576(98)00028-8
发表时间：
1998-11-01
期刊：
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
影响因子：
--
作者：
Clapp, JF;Kiess, W
通讯作者：
Kiess, W
DOI：
10.1016/s0002-9378(03)00828-7
发表时间：
2003-12-01
影响因子：
9.8
作者：
Catalano, PM;Thomas, A;Amini, SB
通讯作者：
Amini, SB