Prickle1b mediates interpretation of migratory cues during zebrafish facial branchiomotor neuron migration.
Prickle1b mediates interpretation of migratory cues during zebrafish facial branchiomotor neuron migration.
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DOI：
10.1002/dvdy.22283
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发表时间：
2010-06
影响因子：
2.5
通讯作者：
Prince, Victoria E.
中科院分区：
文献类型：
--
作者：
Mapp, Oni M.;Wanner, Sarah J.;Rohrschneider, Monica R.;Prince, Victoria E.
关键词：
面鳃神经元在脊椎动物后脑中经历特征性的切线迁移。在这个过程中涉及几种信号传导机制，包括非经典Wnt/平面细胞极性（PCP）途径。然而，这种信号通路在控制这些神经元动力学中的作用尚不清楚。在这里，我们描述了面部神经元迁移的细胞动力学，重点是迁移的速度和方向，突起的延伸，细胞的形状和方向。此外，我们表明，PET/LIM结构域蛋白Prickle 1b（Pk 1b）是这些迁移行为的几个方面所需的，包括细胞定向。然而，我们发现中心体定位并没有受到Pk 1b功能破坏的显著影响，这表明神经元的极化并没有完全丧失。总之，我们的数据表明，Pk 1b功能可能需要将神经元收到的多种迁移线索整合到正确的后部运动的极化指令中。
The facial branchiomotor neurons undergo a characteristic tangential migration in the vertebrate hindbrain. Several signaling mechanisms have been implicated in this process, including the non-canonical Wnt/planar cell polarity (PCP) pathway. However, the role of this signaling pathway in controlling the dynamics of these neurons is unclear. Here, we describe the cellular dynamics of the facial neurons as they migrate, focusing on the speed and direction of migration, extension of protrusions, cell shape and orientation. Furthermore, we show that the PET/LIM domain protein Prickle1b (Pk1b) is required for several aspects of these migratory behaviors, including cell orientation. However, we find that centrosome localization is not significantly affected by disruption of Pk1b function, suggesting that polarization of the neurons is not completely lost. Together, our data suggest that Pk1b function may be required to integrate the multiple migratory cues received by the neurons into polarization instructions for proper posterior movement.
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影响因子：
4.6
作者：
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通讯作者：
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影响因子：
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DOI：
10.1073/pnas.0406382102
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作者：
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通讯作者：
SCHILLING, TF