Modulation of Intestinal TLR4-Inflammatory Signaling Pathways by Probiotic Microorganisms: Lessons Learned from Lactobacillus jensenii TL2937.
Modulation of Intestinal TLR4-Inflammatory Signaling Pathways by Probiotic Microorganisms: Lessons Learned from Lactobacillus jensenii TL2937.
复制标题
通过益生菌微生物对肠道TLR4炎症通路的调节：从Jensenii TL2937中学到的经验教训。
DOI：
10.3389/fimmu.2013.00512
复制
发表时间：
2014-01-14
影响因子：
7.3
通讯作者：
Kitazawa H
中科院分区：
文献类型：
--
作者：
Villena J;Kitazawa H
肠道黏膜在宿主与无害共生菌群和入侵病原微生物的相互作用中起着至关重要的作用。肠上皮细胞（IECs）和肠道相关免疫细胞通过模式识别受体（PRRs）识别细菌成分，并负责维持对大量常驻肠道细菌的耐受性，同时也能够对病原体产生炎症反应。toll样受体（TLRs）是一类主要的PRRs，存在于内皮细胞和免疫细胞上，参与诱导耐受性和炎症。越来越多的实验和临床证据支持益生菌对几种胃肠道炎症性疾病的治疗和预防应用，其中tlr发挥着重要作用。本文综述了具有调节免疫系统能力的益生菌微生物（免疫生物）在猪肠道炎症调节中的有益作用，这对于家畜和人类模型都是非常重要的。我们特别讨论了TLRs的作用，它们的信号通路，以及它们的负调节因子在炎症性肠损伤和免疫生物制剂的有益作用中的作用，特别是jensen乳杆菌TL2937。本文综述了免疫生物通过tlr与内皮细胞和免疫细胞的细胞和分子相互作用及其在改善动物和人类健康方面的应用。
The intestinal mucosa plays a critical role in the host’s interactions with innocuous commensal microbiota and invading pathogenic microorganisms. Intestinal epithelial cells (IECs) and gut associated immune cells recognize the bacterial components via pattern-recognition receptors (PRRs) and are responsible for maintaining tolerance to the large communities of resident luminal bacteria while being also able to mount inflammatory responses against pathogens. Toll-like receptors (TLRs) are a major class of PRRs that are present on IECs and immune cells which are involved in the induction of both tolerance and inflammation. A growing body of experimental and clinical evidence supports the therapeutic and preventive application of probiotics for several gastrointestinal inflammatory disorders in which TLRs exert a significant role. This review aims to summarize the current knowledge of the beneficial effects of probiotic microorganisms with the capacity to modulate the immune system (immunobiotics) in the regulation of intestinal inflammation in pigs, which are very important as both livestock and human model. Especially we discuss the role of TLRs, their signaling pathways, and their negative regulators in both the inflammatory intestinal injury and the beneficial effects of immunobiotics in general, and Lactobacillus jensenii TL2937 in particular. This review article emphasizes the cellular and molecular interactions of immunobiotics with IECs and immune cells through TLRs and their application for improving animal and human health.
登录
查看更多内容
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
2.4
作者：
Deng, Jun;Li, Yunfeng;Yang, Qian
通讯作者：
Yang, Qian
影响因子：
3.1
作者：
Drakes, M;Blanchard, T;Czinn, S
通讯作者：
Czinn, S
影响因子：
30.5
作者：
Boone, DL;Turer, EE;Ma, A
通讯作者：
Ma, A
影响因子：
0.4
作者：
Cui, C.;Shen, C. J.;Wang, K. N.
通讯作者：
Wang, K. N.