Resting-state EEG source localization and functional connectivity in schizophrenia-like psychosis of epilepsy.
Resting-state EEG source localization and functional connectivity in schizophrenia-like psychosis of epilepsy.
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DOI：
10.1371/journal.pone.0027863
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Takeda M
中科院分区：
文献类型：
--
作者：
Canuet L;Ishii R;Pascual-Marqui RD;Iwase M;Kurimoto R;Aoki Y;Ikeda S;Takahashi H;Nakahachi T;Takeda M
目前尚不清楚是否像精神分裂症一样，精神分裂症相关的某些区域之间的连接中断，作为内在功能解体的指标，发生在精神分裂症样癫痫精神病（SLPE）中。在这项研究中，我们试图确定与非精神病性癫痫患者相比，SLPE患者的静息态脑电图振荡和功能连接的异常模式，并评估与精神病理缺陷的相关性。记录了21例局灶性癫痫和SLPE患者和21例临床匹配的非精神病性癫痫对照的静息EEG。使用eLORETA软件确定源电流密度和功能连接性。对于连通性分析，使用了一种新的称为“滞后相位同步”的非线性连通性度量。我们发现，增加θ振荡的默认模式网络（DMN），即内侧和外侧顶叶皮层双边在精神病患者相对于他们的非精神病患者。此外，精神病患者的大脑半球的β颞-前额叶连接性增加，主要是癫痫发作。颞-前额叶回路的这种功能性连接与阳性症状相关。此外，受影响的颞叶和布罗卡区的听觉皮层之间的半球间相位同步增加，与幻听评分相关。除了作为DMN的一部分的顶叶区域的功能障碍之外，静息状态中断的内侧颞叶皮层与参与DMN或涉及精神病理功能障碍的前额叶区域的连接可能对精神分裂症样精神病至关重要，特别是在颞叶癫痫患者中。这表明DMN缺陷可能是该疾病的核心神经生物学特征，并且θ振荡和β相同步的异常代表了潜在的神经活动。
It is unclear whether, like in schizophrenia, psychosis-related disruption in connectivity between certain regions, as an index of intrinsic functional disintegration, occurs in schizophrenia-like psychosis of epilepsy (SLPE). In this study, we sought to determine abnormal patterns of resting-state EEG oscillations and functional connectivity in patients with SLPE, compared with nonpsychotic epilepsy patients, and to assess correlations with psychopathological deficits. Resting EEG was recorded in 21 patients with focal epilepsy and SLPE and in 21 clinically-matched non-psychotic epilepsy controls. Source current density and functional connectivity were determined using eLORETA software. For connectivity analysis, a novel nonlinear connectivity measure called “lagged phase synchronization” was used. We found increased theta oscillations in regions involved in the default mode network (DMN), namely the medial and lateral parietal cortex bilaterally in the psychotic patients relative to their nonpsychotic counterparts. In addition, patients with psychosis had increased beta temporo-prefrontal connectivity in the hemisphere with predominant seizure focus. This functional connectivity in temporo-prefrontal circuits correlated with positive symptoms. Additionally, there was increased interhemispheric phase synchronization between the auditory cortex of the affected temporal lobe and the Broca's area correlating with auditory hallucination scores. In addition to dysfunction of parietal regions that are part of the DMN, resting-state disrupted connectivity of the medial temporal cortex with prefrontal areas that are either involved in the DMN or implicated in psychopathological dysfunction may be critical to schizophrenia-like psychosis, especially in individuals with temporal lobe epilepsy. This suggests that DMN deficits might be a core neurobiological feature of the disorder, and that abnormalities in theta oscillations and beta phase synchronization represent the underlying neural activity.
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影响因子：
2.2
作者：
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