Patterns of word-list generation in mild cognitive impairment and Alzheimer's disease.
Patterns of word-list generation in mild cognitive impairment and Alzheimer's disease.
复制标题
DOI：
10.1080/13854040802585063
复制
发表时间：
2009-07
期刊：
影响因子：
--
通讯作者：
Manning KJ
中科院分区：
文献类型：
--
作者：
Brandt J;Manning KJ
遗忘型轻度认知障碍（aMCI）患者在类别流畅性测试中表现出比字母流畅性更大的障碍。这已被提供作为证据，表明这种情况代表临床前阿尔茨海默病（AD）。我们假设这种差异性损伤的模式取决于特定的语义类别和所选的首字母，而不是AD和aMCI所特有的。共40名认知正常的老年人，74名MCI患者-25名“遗忘单域”（aMCI），27名“遗忘多域”，22名非遗忘-和29名AD患者进行了多种形式的语义类别和首字母流畅性任务的测试。组内和组间的缺陷模式高度依赖于所选的特定类别和字母。总体而言，aMCI患者在类别方面的损害并不比字母流畅性更大。事实上，他们的表现水平和模式与认知正常的老年人比AD患者更相似。多个认知领域缺陷的MCI患者表现得最像AD患者。这些结果表明，言语流畅性的表现是高度影响的具体任务使用，和损害的语义流畅性不是纯粹的遗忘MCI的特点。
Patients with amnestic mild cognitive impairment (aMCI) have been described as exhibiting greater impairment on tests of category fluency than letter fluency. This has been offered as evidence that this condition represents pre-clinical Alzheimer’s disease (AD). We hypothesized that this pattern of differential impairment is dependent on the specific semantic categories and initial letters selected, and is not specific to AD and aMCI. A total of 40 cognitively normal older adults, 74 MCI patients—25 “amnestic single domain” (aMCI), 27 “amnestic multiple domain”, and 22 non-amnestic—and 29 AD patients were tested with multiple forms of semantic-category and initial-letter fluency tasks. The pattern of deficits within and across groups was highly dependent on the specific categories and letters chosen. Overall, aMCI patients did not demonstrate greater impairment in category than letter fluency. In fact, the level and pattern of their performance resembled that of cognitively normal older adults much more than AD patients. MCI patients with deficits in multiple cognitive domains performed most like AD patients. These findings indicate that verbal fluency performance is highly influenced by the specific tasks used, and impairment on semantic fluency is not characteristic of pure amnestic MCI.
登录
查看更多内容
DOI：
10.1080/01688639608408304
发表时间：
1996-12-01
影响因子：
2.2
作者：
Barr, A;Brandt, J
通讯作者：
Brandt, J
影响因子：
--
作者：
Loonstra, A S;Tarlow, A R;Sellers, A H
通讯作者：
Sellers, A H
影响因子：
11
作者：
Lopez, OL;Becker, JT;Kuller, LH
通讯作者：
Kuller, LH
影响因子：
2.4
作者：
Rasquin, SMC;Lodder, J;Verhey, FRJ
通讯作者：
Verhey, FRJ
影响因子：
2.4
作者：
Rascovsky, Katya;Salmon, David P.;Galasko, Douglas
通讯作者：
Galasko, Douglas