Psychosis Biotypes: Replication and Validation from the B-SNIP Consortium.
Psychosis Biotypes: Replication and Validation from the B-SNIP Consortium.
复制标题
精神病生物型：B-SNIP联盟的复制和验证。
DOI：
10.1093/schbul/sbab090
复制
发表时间：
2022-01-21
影响因子：
6.6
通讯作者：
Tamminga CA
中科院分区：
文献类型：
--
作者：
Clementz BA;Parker DA;Trotti RL;McDowell JE;Keedy SK;Keshavan MS;Pearlson GD;Gershon ES;Ivleva EI;Huang LY;Hill SK;Sweeney JA;Thomas O;Hudgens-Haney M;Gibbons RD;Tamminga CA
目前精神病学的临床现象学诊断既不能捕获生物学上同源的疾病实体，也不允许基于神经生物学的个体化治疗处方。在这份报告中，我们研究了两个大样本的情况下，精神分裂症，情感障碍，双相I型精神障碍与精神病，介绍与幻觉，妄想，思维障碍，情感，或阴性症状的临床特征。一种对精神病病例进行亚型分型的生物标志物方法（称为精神病生物型）捕获了传统临床诊断所遗漏的神经生物学同源性。两个样品（称为“B-SNIP 1”，711名精神病患者和274名健康人，以及“复制样本”，717名精神病患者和198名健康人）显示，44个个体生物标志物，来自一般认知（BACS），运动抑制，（停止信号），扫视系统（支持和反对扫视），听觉EEG/ERP精神病相关脑功能的（成对刺激和古怪）任务是可复制的（r从.96-.99）和时间稳定的（r从.76-.95）。使用具有九组综合生物标志物特征（称为生物因子）的数值分类法（k均值聚类）产生了三种生物型，这三种生物型在两个样品之间几乎相同，并且基于交叉验证（88.5%-89%）显示出高度相似的亚组病例分配。生物型1和生物型2的认知能力较差。生物型-1的进一步特征在于低神经反应幅度，而生物型-2的进一步特征在于过度活跃的神经反应和差的感觉运动抑制。生物型-3在所有生物因子上几乎正常。使用内在神经活动和听觉稳态刺激的措施对生物型EEG/ERP神经生理学进行结构验证，突出了这些结果的稳健性。精神病生物型可能会产生有意义的神经生物学治疗和病因调查的目标。
Current clinical phenomenological diagnosis in psychiatry neither captures biologically homologous disease entities nor allows for individualized treatment prescriptions based on neurobiology. In this report, we studied two large samples of cases with schizophrenia, schizoaffective, and bipolar I disorder with psychosis, presentations with clinical features of hallucinations, delusions, thought disorder, affective, or negative symptoms. A biomarker approach to subtyping psychosis cases (called psychosis Biotypes) captured neurobiological homology that was missed by conventional clinical diagnoses. Two samples (called “B-SNIP1” with 711 psychosis and 274 healthy persons, and the “replication sample” with 717 psychosis and 198 healthy persons) showed that 44 individual biomarkers, drawn from general cognition (BACS), motor inhibitory (stop signal), saccadic system (pro- and anti-saccades), and auditory EEG/ERP (paired-stimuli and oddball) tasks of psychosis-relevant brain functions were replicable (r’s from .96–.99) and temporally stable (r’s from .76–.95). Using numerical taxonomy (k-means clustering) with nine groups of integrated biomarker characteristics (called bio-factors) yielded three Biotypes that were virtually identical between the two samples and showed highly similar case assignments to subgroups based on cross-validations (88.5%–89%). Biotypes-1 and -2 shared poor cognition. Biotype-1 was further characterized by low neural response magnitudes, while Biotype-2 was further characterized by overactive neural responses and poor sensory motor inhibition. Biotype-3 was nearly normal on all bio-factors. Construct validation of Biotype EEG/ERP neurophysiology using measures of intrinsic neural activity and auditory steady state stimulation highlighted the robustness of these outcomes. Psychosis Biotypes may yield meaningful neurobiological targets for treatments and etiological investigations.
登录
查看更多内容
DOI：
10.1176/appi.ajp.2015.14091200
发表时间：
2016-04-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Clementz BA;Sweeney JA;Hamm JP;Ivleva EI;Ethridge LE;Pearlson GD;Keshavan MS;Tamminga CA
通讯作者：
Tamminga CA
DOI：
10.1038/npp.2009.32
发表时间：
2009-08
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.6
作者：
Hall, Mei Hua;Schulze, Katja;Sham, Pak
通讯作者：
Sham, Pak
影响因子：
6.6
作者：
Cheng, Chia-Hsiung;Chan, Pei-Ying S.;Hsu, Shih-Chieh
通讯作者：
Hsu, Shih-Chieh
影响因子：
34.7
作者：
Casey, B. J.;Craddock, Nick;Cuthbert, Bruce N.;Hyman, Steven E.;Lee, Francis S.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.