The hippocampus and orbitofrontal cortex jointly represent task structure during memory-guided decision making.
The hippocampus and orbitofrontal cortex jointly represent task structure during memory-guided decision making.
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DOI：
10.1016/j.celrep.2021.110065
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发表时间：
2021-11-30
期刊：
影响因子：
8.8
通讯作者：
Ranganath C
中科院分区：
文献类型：
--
作者：
Mızrak E;Bouffard NR;Libby LA;Boorman ED;Ranganath C
海马体以其在情景记忆中的作用而闻名，它也可能是一个重要的大脑区域，可以从我们的经验中提取结构，以指导未来的决定。最近的证据表明，在啮齿动物海马支持决策的任务结构与眶额皮质（OFC）的合作。在这里，我们研究人类海马和OFC表示任务结构在一个关联的学习任务，需要学习的上下文确定的和上下文不变的概率协会。我们发现，学习后，海马和侧OFC表示区分上下文决定和上下文不变的任务结构。海马和外侧OFC内的这种分化程度是高度相关的。这些结果推进了我们对海马的理解，并表明海马和眶额皮层通过代表指导选择适当决策策略的信息来支持目标导向行为。Mizrak等人使用功能性磁共振成像证明，海马和眶额皮层在共享相同任务子结构的决策中与不同任务子结构相比具有泛化能力。结果表明，海马，在协调OFC，支持决策提取结构从过去的经验。
The hippocampus, well known for its role in episodic memory, might also be an important brain region for extracting structure from our experiences in order to guide future decisions. Recent evidence in rodents suggests that the hippocampus supports decision making by representing task structure in cooperation with the orbitofrontal cortex (OFC). Here, we examine how the human hippocampus and OFC represent task structure during an associative learning task that required learning of both context-determined and context-invariant probabilistic associations. We find that after learning, hippocampal and lateral OFC representations differentiated between context-determined and context-invariant task structures. The degree of this differentiation within the hippocampus and lateral OFC is highly correlated. These results advance our understanding of the hippocampus and suggest that the hippocampus and OFC support goal-directed behavior by representing information that guides the selection of appropriate decision strategies. Mizrak et al. use fMRI to demonstrate that hippocampus and orbitofrontal cortex generalize across decisions that share the same task sub-structure compared with different task sub-structures. Results show that the hippocampus, in coordination with OFC, supports decision making by extracting structure from past experiences.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
DOI：
10.1523/jneurosci.5458-12.2013
发表时间：
2013-05-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Komorowski RW;Garcia CG;Wilson A;Hattori S;Howard MW;Eichenbaum H
通讯作者：
Eichenbaum H
影响因子：
16.6
作者：
Horner AJ;Bisby JA;Bush D;Lin WJ;Burgess N
通讯作者：
Burgess N
影响因子：
16.2
作者：
McKenzie S;Frank AJ;Kinsky NR;Porter B;Rivière PD;Eichenbaum H
通讯作者：
Eichenbaum H
影响因子：
16.2
作者：
Knudsen, Eric B.;Wallis, Joni D.
通讯作者：
Wallis, Joni D.