Conductive gelatin methacrylate-poly(aniline) hydrogel for cell encapsulation
Conductive gelatin methacrylate-poly(aniline) hydrogel for cell encapsulation
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用于细胞封装的导电明胶甲基丙烯酸酯-聚苯胺水凝胶
DOI：
10.1088/2057-1976/aa91f9
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发表时间：
2018
影响因子：
1.4
通讯作者：
Soman, Pranav
中科院分区：
文献类型：
--
作者：
Sawyer, Stephen W;Dong, Ping;Venn, Sarah;Ramos, Andrew;Quinn, David;Horton, Jason A;Soman, Pranav
具有上级生物相容性的新型导电水凝胶继续被开发，以作为能够调节细胞功能的生物活性支架用于组织工程应用。我们开发了一种导电的明胶甲基丙烯酸酯-聚（苯胺）（GelMA-PANi）水凝胶，其允许通过包封的成骨细胞样细胞进行基质矿化。在GelMA基质中掺入PANi簇增加了复合凝胶的电导率，同时保持了类骨质软机械性能，允许活细胞的三维封装。包封在GelMA-PANi水凝胶内的人成骨细胞的活力与GelMA相似。GelMA-PANi内的细胞也证明了在化学诱导两周后在水凝胶基质内沉积矿物质的能力，尽管与GelMA相比，总矿物质含量较低。此外，我们证明了GelMA-PANi复合水凝胶可以使用数字投影立体光刻以复杂的用户定义的几何形状打印。
New conductive hydrogels with superior biocompatibility continue to be developed in order to serve as bioactive scaffolds capable of modulating cellular functionality for tissue engineering applications. We developed an electrically conductive gelatin methacrylate-poly (aniline)(GelMA-PANi) hydrogel that is permissive of matrix mineralization by encapsulated osteoblast-like cells. Incorporation of PANi clusters within the GelMA matrix increases the electro-conductivity of the composite gel, while maintaining the osteoid-like soft mechanical properties that allows three-dimensional encapsulation of living cells. Viability of human osteogenic cells encapsulated within GelMA-PANi hydrogels was similar to that of GelMA. Cells within GelMA-PANi also demonstrated the capability of depositing mineral within the hydrogel matrix after being chemically induced for two weeks, although the total mineral content was lower as compared to GelMA. Additionally, we demonstrated that the GelMA-PANi-composite hydrogel could be printed in complex, user-defined geometries using digital projection stereolithography.
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影响因子：
3.8
作者：
Tibbitt, Mark W.;Anseth, Kristi S.
通讯作者：
Anseth, Kristi S.
影响因子：
14
作者：
Yue K;Trujillo-de Santiago G;Alvarez MM;Tamayol A;Annabi N;Khademhosseini A
通讯作者：
Khademhosseini A
影响因子：
17.1
作者：
Shin, Su Ryon;Jung, Sung Mi;Zalabany, Momen;Kim, Keekyoung;Zorlutuna, Pinar;Kim, Sang Bok;Nikkhah, Mehdi;Khabiry, Masoud;Azize, Mohamed;Kong, Jing;Wan, Kai-tak;Palacios, Tomas;Dokmeci, Mehmet R.;Bae, Hojae;Tang, Xiaowu (Shirley);Khademhosseini, Ali
通讯作者：
Khademhosseini, Ali
用于细胞培养的新型悬浮水凝胶膜平台
DOI：
--
发表时间：
2015
期刊：
影响因子：
--
作者：
Y. X. Chen;Shih;Jiahan Yan;M. Hsieh;Lingyan Weng;Jessica L. Ouderkirk;M. Krendel;P. Soman
通讯作者：
P. Soman
影响因子：
5
作者：
Lewis, Katherine J. R.;Anseth, Kristi S.
通讯作者：
Anseth, Kristi S.