Reorganization of corticospinal output during motor learning.
Reorganization of corticospinal output during motor learning.
复制标题
DOI：
10.1038/nn.4596
复制
发表时间：
2017-08
影响因子：
25
通讯作者：
Komiyama T
中科院分区：
文献类型：
--
作者：
Peters AJ;Lee J;Hedrick NG;O'Neil K;Komiyama T
运动学习伴随着运动皮层内的广泛变化，但尚不清楚这些变化最终是否通过稳定的皮质脊髓输出通道，或者皮质脊髓输出本身是否具有可塑性。我们通过在体双光子钙离子成像研究了小鼠学习压下任务时皮质脊髓神经元活动与运动之间关系的一致性。皮质脊髓神经元表现出与运动的异质相关性，大多数运动调制神经元在运动过程中活动减少。个体细胞在几天内改变了它们的活性，这导致了皮质脊髓活性和运动之间的新关联。与之前在第2/3层的观察不同，伴随学习动作的活动并没有变得与学习更加一致，相反，不同动作的活动变得更加去相关。这些结果表明，皮质脊髓活动和运动之间的关系是动态的，和类型的活动和可塑性是不同的，并可能补充层2/3。
Motor learning is accompanied by widespread changes within the motor cortex, but it is unknown whether these changes are ultimately funneled through a stable corticospinal output channel or if the corticospinal output itself is plastic. We investigated the consistency of the relationship between corticospinal neuron activity and movement through in vivo two-photon calcium imaging in mice learning a lever-press task. Corticospinal neurons exhibited heterogeneous correlations with movement, with the majority of movement-modulated neurons decreasing activity during movement. Individual cells changed their activity across days which led to novel associations between corticospinal activity and movement. Unlike previous observations in layer 2/3, activity accompanying learned movements did not become more consistent with learning, and instead the activity of dissimilar movements became more decorrelated. These results indicate that the relationship between corticospinal activity and movement is dynamic, and the types of activity and plasticity are different from and possibly complementary to layer 2/3.
登录
查看更多内容
影响因子：
3.1
作者：
Bacskai, Timea;Fu, Yuhong;Watson, Charles
通讯作者：
Watson, Charles
影响因子：
5.3
作者：
Brus-Ramer, Marcel;Carmel, Jason B.;Martin, John H.
通讯作者：
Martin, John H.
DOI：
10.1523/jneurosci.5717-11.2012
发表时间：
2012-04-25
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kita T;Kita H
通讯作者：
Kita H
DOI：
10.1126/science.aaa8035
发表时间：
2015-11-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Griffin DM;Hoffman DS;Strick PL
通讯作者：
Strick PL
Vibrissa运动皮层活性抑制对侧搅拌行为。
影响因子：
25
作者：
Ebbesen CL;Doron G;Lenschow C;Brecht M
通讯作者：
Brecht M