Early colonization with a group of Lactobacilli decreases the risk for allergy at five years of age despite allergic heredity.
Early colonization with a group of Lactobacilli decreases the risk for allergy at five years of age despite allergic heredity.
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DOI：
10.1371/journal.pone.0023031
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Sverremark-Ekström E
中科院分区：
文献类型：
--
作者：
Johansson MA;Sjögren YM;Persson JO;Nilsson C;Sverremark-Ekström E
生命早期的微生物剥夺可能会影响免疫介导的疾病的发展，例如过敏。本研究的目的是调查父母过敏对婴儿肠道定植的影响以及婴儿肠道微生物群与五岁时过敏性疾病之间的关联。研究人员分别在婴儿出生后 1 周、2 周以及 1、2 个月和 12 个月时从过敏或非过敏父母的 58 名婴儿身上采集了粪便样本。从粪便样本中提取 DNA，并使用物种特异性引物进行实时 PCR 检测青春双歧杆菌 (B.)、短双歧杆菌、双歧杆菌、艰难梭菌 (C.)、一组乳杆菌（干酪乳杆菌、副干酪乳杆菌和鼠李糖乳杆菌）以及金黄色葡萄球菌。与父母过敏的婴儿相比，父母不过敏的婴儿更容易被乳酸杆菌定植（p = 0.014）。然而，无论父母是否过敏，非过敏性五岁儿童在出生后的最初几周内比过敏性儿童更容易感染乳酸杆菌（p = 0.009，p = 0.028）。此外，非过敏儿童在出生后的头两个月内更多地被乳酸菌定植（p = 0.038）。此外，一周龄时被两歧双歧杆菌定植的非过敏儿童明显多于五岁时过敏的儿童（p = 0.048）。在这项研究中，我们表明过敏遗传对婴儿肠道微生物群有影响，而且尽管存在过敏遗传，但早期乳杆菌（干酪乳杆菌、副干酪乳杆菌、鼠李糖乳杆菌）定植似乎会降低五岁时过敏的风险。
Microbial deprivation early in life can potentially influence immune mediated disease development such as allergy. The aims of this study were to investigate the influence of parental allergy on the infant gut colonization and associations between infant gut microbiota and allergic disease at five years of age. Fecal samples were collected from 58 infants, with allergic or non-allergic parents respectively, at one and two weeks as well as at one, two and twelve months of life. DNA was extracted from the fecal samples and Real time PCR, using species-specific primers, was used for detection of Bifidobacterium (B.) adolescentis, B. breve, B. bifidum, Clostridium (C.) difficile, a group of Lactobacilli (Lactobacillus (L.) casei, L. paracasei and L. rhamnosus) as well as Staphylococcus (S.) aureus. Infants with non-allergic parents were more frequently colonized by Lactobacilli compared to infants with allergic parents (p = 0.014). However, non-allergic five-year olds acquired Lactobacilli more frequently during their first weeks of life, than their allergic counterparts, irrespectively of parental allergy (p = 0.009, p = 0.028). Further the non-allergic children were colonized with Lactobacilli on more occasions during the first two months of life (p = 0.038). Also, significantly more non-allergic children were colonized with B. bifidum at one week of age than the children allergic at five years (p = 0.048). In this study we show that heredity for allergy has an impact on the gut microbiota in infants but also that early Lactobacilli (L. casei, L. paracasei, L. rhamnosus) colonization seems to decrease the risk for allergy at five years of age despite allergic heredity.
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影响因子：
14.2
作者：
Adlerberth, Ingegerd;Strachan, David P.;Wold, Agnes E.
通讯作者：
Wold, Agnes E.
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
6.1
作者：
Martino, D. J.;Currie, H.;Prescott, S. L.
通讯作者：
Prescott, S. L.
影响因子：
6.1
作者：
Lundell, A-C.;Adlerberth, I.;Rudin, A.
通讯作者：
Rudin, A.
影响因子：
4.4
作者：
Fink, Lisbeth N.;Zeuthen, Louise H.;Ferlazzo, Guido
通讯作者：
Ferlazzo, Guido